ArticleVirchows Archiv : an international journal of pathology2020
MAML2 rearrangement as a useful diagnostic marker discriminating between Warthin tumour and Warthin-like mucoepidermoid carcinoma.
Article in Virchows Archiv : an international journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Clinicopathological Analysis of Salivary Glands Warthin-like Mucoepidermoid Carcinoma: A Systematic Review.Head and neck pathology · 2025Pooled it
- Pathogenesis of Warthin's Tumors: A Critical Synthesis of the Evidence.Head and neck pathology · 2026Review
- Characterizing Warthin-Like Mucoepidermoid Carcinoma: Clinicopathologic Features and MAML2 Rearrangements in 14 Latin American Cases.Head and neck pathology · 2026Article
- A case of infarcted Warthin tumor misdiagnosed as Warthin-like mucoepidermoid carcinoma: diagnosis confirmed byFrontiers in oncology · 2026Article
- Genomic profiling and HER2-targeted therapy: a case series of Chinese salivary duct carcinoma patients and its clinical implications.Frontiers in oncology · 2026Article
- Benign Epithelial Salivary Neoplasms: Single-Centered Histopathologic and Clinicodemographic Romanian Retrospective Study.Clinics and practice · 2025Article
- Association Between the Histological Subtypes, Anatomical Locations, and MAML2 Rearrangement of Head and Neck Mucoepidermoid Carcinoma.Head and neck pathology · 2025Article
- Parotid Gland Tumors: Molecular Diagnostic Approaches.International journal of molecular sciences · 2024Review
- MAML2 gene rearrangement occurs in all Warthin-like mucoepidermoid carcinoma: A reappraisal in a series of 29 cases.Heliyon · 2024Article
- Case report: The diagnostic pitfall of Warthin-like mucoepidermoid carcinoma.Frontiers in oncology · 2024Article
- KRAS codon 12 mutations characterize a subset of de novo proliferating "metaplastic" Warthin tumors.Virchows Archiv : an international journal of pathology · 2023Article
- Top Ten Oncocytic Head and Neck Lesions to Contemplate.Head and neck pathology · 2023Review
- Warthin-like mucoepidermoid carcinoma of the parotid gland: a clinicopathological analysis of two cases.The Journal of international medical research · 2022Article
- Diagnostic Value of MAML2 Rearrangements in Mucoepidermoid Carcinoma.International journal of molecular sciences · 2022Article
- Warthin-like mucoepidermoid carcinoma and mucoepidermoid carcinoma, mucinous metaplasia involving Warthin tumor: three case reports.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Fine-needle aspiration cytology of Warthin-like mucoepidermoid carcinoma: A case report with cytological review.Molecular and clinical oncology · 2022Article
- Current Trends and Controversies in the Management of Warthin Tumor of the Parotid Gland.Diagnostics (Basel, Switzerland) · 2021Review
- Molecular and Cellular Modelling of Salivary Gland Tumors Open New Landscapes in Diagnosis and Treatment.Cancers · 2020Review
- Warthin-like mucoepidermoid carcinoma of the parotid gland: Clinicopathological observation and literature review.Science progressReview
- Warthin-like Mucoepidermoid Carcinoma in an Elderly Male Patient: A Case Report.In vivo (Athens, Greece)Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Warthin tumour is the second most common benign neoplasm of salivary glands. Despite its relatively characteristic histology, it may sometimes mimic other lesions. Here, we report two female non-smoker patients diagnosed with low-grade mucoepidermoid carcinoma with oncocytic epithelium and prominent lymphoid (Warthin-like) stroma and with molecularly confirmed MAML2 rearrangement. In addition, we screened a consecutive series of 114 Warthin tumour cases by means of MAML2 break apart fluorescence in situ hybridization to assess its value in differential diagnosis. MAML2 rearrangement was detected in both mucoepidermoid carcinoma cases, while all Warthin tumours were negative. Taking into account the literature data, Warthin-like mucoepidermoid carcinomas are more frequently observed in women, while a slight male predominance and smoking history are typical for Warthin tumour. In addition, the patients with Warthin-like mucoepidermoid carcinoma were significantly younger than those with Warthin tumour. To conclude, Warthin-like mucoepidermoid carcinoma may usually be suspected based on histology, while the diagnosis can be confirmed by means of molecular assays such as FISH. The investigation of MAML2 status is particularly advised when Warthin tumour is considered in a young, non-smoking, female patient.
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