Evidence map›Paper›PMID 32222812›Full record

GuidelineIntensive care medicine2020

Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19).

Waleed Alhazzani, Morten Hylander Møller, Yaseen M Arabi, Mark Loeb, Michelle Ng Gong, Eddy Fan, Simon Oczkowski, Mitchell M Levy, Lennie Derde, Amy Dzierba and 26 more

9 registry-linked trialsAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Intensive care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 9 registered trials, which are not on this map. Cited by 1,089 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,089citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04380935 phase2 / phase3unknown statusnot on this map

Effectiveness and Safety of Convalescent Plasma Therapy on COVID-19 Patients With Acute Respiratory Distress Syndrome in Referral Hospitals in Indonesia

TypeinterventionalSponsorIndonesia UniversityRan2020 to 2020Enrolled60ConditionsCOVID, Acute Respiratory Distress SyndromeArmsConvalescent plasma, Standard of care
NCT04454372 completednot on this map

Clinical Characteristics and Outcomes of 187 Critically Ill Patients With COVID-19

TypeobservationalSponsorHospital Sao DomingosRan2020 to 2020Enrolled187ConditionsCOVID-19Armsdemographic and clinical data obtained from hospital's electronic medical record.
NCT04540926 phase1 / phase2unknown statusnot on this map

Utility of Low Doses of Corticosteroids and Cyclosporine Combined With Enoxaparin, in Patients With COVID-19 Pneumonia at the ISSSTE Regional Hospital, Puebla, During the Contingency Period Due to the SARS-Cov2 Pandemic

TypeinterventionalSponsorInstituto de Seguridad y Servicios Sociales de los Trabajadores del EstadoRan2020 to 2020Enrolled200ConditionsCOVID 19 PneumoniaArmsCyclosporin A
NCT04706325 unknown statusnot on this mapstarted 2021, after this paper: background citation

Investigation of risk factors related to covid-19 related kidney damage: a prospective observational study

TypeobservationalSponsorKocaeli Derince Education and Research HospitalRan2021 to 2021Enrolled100ConditionsAcute Kidney InjuryArmsACUTE KIDNEY INJURY
NCT04725084 completednot on this map

Comparison of Non-invasive Oxygenation Strategies in ICU Patients Admitted for Covid-19 Acute Respiratory Distress Syndrome

TypeobservationalSponsorCentre Hospitalier Intercommunal de Toulon La Seyne sur MerRan2020 to 2020Enrolled355ConditionsSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)ArmsUse of High Flow Nasal Cannula alone, Use of Non-invasive Ventilation, Use of Continuous Positive Airway Pressure
NCT04836065 completednot on this map

European Society Of Intensive Care Medicine COVID-19 Project (UNITE-COVID)

TypeobservationalSponsorUniversity Hospital, GhentRan2020 to 2020Enrolled4,995ConditionsCOVID-19 Infection
NCT04900129 phase1completednot on this map

Inhalation of Vapor With Medication (Diclofenac Sodium, Menthol, Methyl Salicylate and N-Acetyl Cysteine) Reduces Oxygen Need and Hospital Stay in COVID-19 Patients - A Case Control Study

TypeinterventionalSponsorSher-E-Bangla Medical CollegeRan2020 to 2020Enrolled43ConditionsCovid19ArmsMenthol 0.02%, Methyl salicylate 0.05%, N- Acetyl cysteine 1.2 gm%, and Diclofenac sodium 1gm%
NCT05216640 naunknown statusnot on this mapstarted 2022, after this paper: background citation

High Flow Nasal Cannula Versus High Velocity Nasal Insufflation in Covid-19 Patients Admitted to Respiratory Intensive Care Unit of Assiut University Hospital

TypeinterventionalSponsorAssiut UniversityRan2022 to 2023Enrolled50ConditionsCOVID-19, Acute Respiratory FailureArmsHigh Flow Oxygen Therapy
NCT05336656 completednot on this mapstarted 2022, after this paper: background citation

Assessment of Analgesics and Sedatives in Mechanically Ventilated Patients With COVID-19

TypeobservationalSponsorWilkes UniversityRan2022 to 2022Enrolled353ConditionsCOVID-19, ARDS, Withdrawal Syndrome, Iatrogenic Disease
3 · Its place in the literature

Who cites it

1,089 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Phase angle and COVID-19: A systematic review with meta-analysis.Reviews in endocrine & metabolic disorders · 2023
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  14. Comparison of the effect of intravenous dexamethasone and methylprednisolone on the treatment of hospitalized patients with COVID-19: a randomized clinical trial.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
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1,029 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors.

Waleed AlhazzaniDepartment of Medicine, McMaster University, Hamilton, Canada.
Morten Hylander MøllerDepartment of Intensive Care, Copenhagen University Hospital Rigshospitalet, 4131, Copenhagen, Denmark.
Yaseen M ArabiIntensive Care Department, Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi Arabia.
Mark LoebDepartment of Medicine, McMaster University, Hamilton, Canada.
Michelle Ng GongDivision of Critical Care Medicine, Division of Pulmonary Medicine, Department of Medicine, Montefiore Healthcare System/Albert Einstein College of Medicine, Bronx, NY, USA.
Eddy FanInterdepartmental Division of Critical Care Medicine, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.
Simon OczkowskiDepartment of Medicine, McMaster University, Hamilton, Canada.
Mitchell M LevyWarren Alpert School of Medicine, Brown University, Providence, RI, USA.
Lennie DerdeDepartment of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Amy DzierbaDepartment of Pharmacy, NewYork-Presbyterian Hospital, Columbia University Irving Medical Center, New York, NY, USA.
Bin DuMedical ICU, Peking Union Medical College Hospital, 1 Shuai Fu Yuan, Beijing, 100730, China.
Michael AboodiDivision of Critical Care Medicine, Division of Pulmonary Medicine, Department of Medicine, Montefiore Healthcare System/Albert Einstein College of Medicine, Bronx, NY, USA.
Hannah WunschDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Maurizio CecconiDepartment of Anesthesia and Intensive Care, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
Younsuck KohDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Daniel S ChertowCritical Care Medicine Department, National Institutes of Health Clinical Center and Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Baltimore, USA.
Kathryn MaitlandFaculty of Medicine, Imperial College, London, UK.
Fayez AlshamsiDepartment of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates.
Emilie Belley-CoteDepartment of Medicine, McMaster University, Hamilton, Canada.
Massimiliano GrecoDepartment of Anesthesia and Intensive Care, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
Matthew LaundyMicrobiology and Infection Control, St George's University Hospitals NHS Foundation Trust & St George's University of London, London, UK.
Jill S MorganEmory University Hospital, Atlanta, USA.
Jozef KeseciogluDepartment of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Allison McGeerDivision of Infectious Diseases, University of Toronto, Toronto, Canada.
Leonard MermelWarren Alpert School of Medicine, Brown University, Providence, RI, USA.
Manoj J MammenDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, USA.ORCID https://orcid.org/0000-0003-0343-3234
Paul E AlexanderDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
Amy ArringtonHouston Children's Hospital, Baylor College of Medicine, Houston, USA.
John E CentofantiDepartment of Anesthesia, McMaster University, Hamilton, Canada.
Giuseppe CiterioDepartment of Medicine and Surgery, Milano-Bicocca University, Milan, Italy.
Bandar BawDepartment of Medicine, McMaster University, Hamilton, Canada.
Ziad A MemishDirector, Research and Innovation Centre, King Saud Medical City, Ministry of Health, Riyadh, Kingdom of Saudi Arabia.
Naomi HammondCritical Care Division, The George Institute for Global Health and UNSW, Sydney, Australia.
Frederick G HaydenDivision of Infectious Diseases and International Health, Department of Medicine, University, of Virginia, School of Medicine, Charlottesville, VA, USA.
Laura EvansDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, USA.
Andrew RhodesAdult Critical Care, St George's University Hospitals NHS Foundation Trust & St George's University of London, London, UK. andrewrhodes@nhs.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed.

methodsWe formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. We searched the literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ICU. We identified relevant and recent systematic reviews on most questions relating to supportive care. We assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak, or in the form of best practice recommendations.

resultsThe Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which 4 are best practice statements, 9 are strong recommendations, and 35 are weak recommendations. No recommendation was provided for 6 questions. The topics were: (1) infection control, (2) laboratory diagnosis and specimens, (3) hemodynamic support, (4) ventilatory support, and (5) COVID-19 therapy.

conclusionThe Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new recommendations in further releases of these guidelines.

Indexed as

Coronavirus InfectionsCOVID-19Critical CareHumansIntensive Care UnitsPandemicsPneumonia, ViralSepsisSurvivorsClinical practice guidelinesCoronavirusCOVID-19Critical illnessSARS CoV-2

Identifiers

PMID32222812
PMCPMC7101866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 3 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.