ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Resist the Temptation of Response-Adaptive Randomization.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07491419 (The Impact of Fast Antimicrobial Sensitivity Testing Tools on Stewardship Antibiotic and Clinical Outcome), which is not on this map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Fast Antimicrobial Sensitivity Testing Tools on Stewardship Antibiotic and Clinical Outcome: a Randomized Clinical Trial Within an Adaptive Platform Trial for Patients With Bloodstream Infections
Who cites it
29 citing papers in PubMed.
- Challenges and opportunities in biomarker-driven trials: adaptive randomization.Annals of translational medicine · 2022Trial
- A roadmap to using randomization in clinical trials.BMC medical research methodology · 2021Trial
- Article
- Minimization of expected balance distribution differences: optimization of the randomized allocation algorithm based on the Pocock-Simon design.BMC medical research methodology · 2026Article
- Assessing the feasibility of a platform trial for Gram negative bloodstream infections: results from the vanguard phase of BALANCE.BMJ open · 2025Article
- Response adaptive randomisation in clinical trials: Current practice, gaps and future directions.Statistical methods in medical research · 2025Article
- Operating characteristics of unequal allocation ratios in platform trials with the staggered addition of drugs using binary endpoints.Contemporary clinical trials communications · 2025Article
- A Preplanned Multi-Stage Platform Trial for Discovering Multiple Superior Treatments With Control of FWER and Power.Biometrical journal. Biometrische Zeitschrift · 2025Article
- Implementation of statistical features of a Bayesian two-armed responsive adaptive randomization trial with post hoc analysis of time trend drift.Journal of biopharmaceutical statistics · 2025Article
- Randomization in clinical trials with small sample sizes using group sequential designs.PloS one · 2025Article
- Adaptive randomization methods for sequential multiple assignment randomized trials (smarts) via thompson sampling.Biometrics · 2024Article
- Optimal allocation strategies in platform trials with continuous endpoints.Statistical methods in medical research · 2024Article
- Adaptive clinical trials in surgery: A scoping review of methodological and reporting quality.PloS one · 2024Article
- Using biomarkers to allocate patients in a response-adaptive clinical trial.Communications in statistics: Simulation and computation · 2023Article
- Bayesian Strategies in Rare Diseases.Therapeutic innovation & regulatory science · 2023Review
- Response-adaptive randomization in clinical trials: from myths to practical considerations.Statistical science : a review journal of the Institute of Mathematical Statistics · 2023Article
- Recent innovations in adaptive trial designs: A review of design opportunities in translational research.Journal of clinical and translational science · 2023Review
- Non-static framework for understanding adaptive designs: an ethical justification in paediatric trials.Journal of medical ethics · 2022Article
- Analysis of adaptive platform trials using a network approach.Clinical trials (London, England) · 2022Article
- Should RECOVERY have used response adaptive randomisation? Evidence from a simulation study.BMC medical research methodology · 2022Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Response-adaptive randomization (RAR) has recently gained popularity in clinical trials. The intent is noble: minimize the number of participants randomized to inferior treatments and increase the amount of information about better treatments. Unfortunately, RAR causes many problems, including (1) bias from temporal trends, (2) inefficiency in treatment effect estimation, (3) volatility in sample-size distributions that can cause a nontrivial proportion of trials to assign more patients to an inferior arm, (4) difficulty of validly analyzing results, and (5) the potential for selection bias and other issues inherent to being unblinded to ongoing results. The problems of RAR are most acute in the very setting for which RAR has been proposed, namely long-duration "platform" trials and infectious disease settings where temporal trends are ubiquitous. Response-adaptive randomization can eliminate the benefits that randomization, the most powerful tool in clinical trials, provides. Use of RAR is discouraged.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.