ArticleChest2020
OSA and Neurocognitive Impairment in Children With Congenital Heart Disease.
Article in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Characteristics of children with congenital heart defects and their caregivers in three U.S. sites: the Congenital Heart Survey To Recognize Outcomes Needs and well-beinG of KIDS (CHSTRONG KIDS).Progress in pediatric cardiology · 2026Article
- A comprehensive review of sleep disordered breathing in people with congenital heart disease.Frontiers in sleep · 2026Review
- Comorbidities in Adolescents With Congenital Heart Disease: A Population-based Study.Pediatrics open science · 2025Article
- The impact of sleep in high-risk infants.Pediatric research · 2025Review
- Dyadic Mental Health in Paediatric Congenital Heart Disease: Actor-Partner Associations Between Child HRQoL/Depression and Caregiver Stress Across Lesion Severity.Healthcare (Basel, Switzerland) · 2025Article
- Utility of caregiver signaling questions to detect neurocognitive impairment in children with sickle cell disease.Blood advances · 2025Article
- Alterations in Amygdala/Hippocampal Volume Ratios in Children with Obstructive Sleep Apnea Syndrome Caused by Adenotonsillar Hypertrophy.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Exercise as therapy for neurodevelopmental and cognitive dysfunction in people with a Fontan circulation: A narrative review.Frontiers in pediatrics · 2023Review
- Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophy.Journal of cachexia, sarcopenia and muscle · 2022Article
- The role of parenting stress in anxiety and sleep outcomes in toddlers with congenital heart disease.Frontiers in pediatrics · 2022Article
- Association Between Sleep Disturbances With Neurodevelopmental Problems and Decreased Health-Related Quality of Life in Children With Fontan Circulation.Journal of the American Heart Association · 2021Article
- Antenatal and Perioperative Mechanisms of Global Neurological Injury in Congenital Heart Disease.Pediatric cardiology · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundChildren with congenital heart disease (CHD) have an increased risk of neurocognitive impairment. No prior studies have evaluated the role of OSA, which is associated with neurocognitive impairment in children without CHD. RESEARCH QUESTION: Is OSA is associated with neurocognitive impairment in children with CHD? STUDY DESIGN AND
methodsChildren aged 6 to 17 years with corrected moderate to complex CHD without syndromes that may affect neurocognition were recruited from the pediatric cardiology clinic. Participants underwent home sleep testing and neurocognitive testing, including a validated Intellectual Quotient (IQ) test as well as validated tests of memory (Paired Associates Learning test), executive function (Intra-Extra Dimensional set shift test), and attention (Simple Reaction Test) from the CANTAB neurocognitive testing battery.
resultsComplete results were available for 30 children. Seventeen children (57%) were found to have OSA. Total IQ was markedly lower in children with CHD and comorbid OSA compared with children with CHD without comorbid OSA (mean, 86 ± 12 vs 98 ± 11; P = .01). Children with CHD and OSA did significantly worse on the Paired Associates Learning test, with a median of eight total errors (interquartile range [IQR], 2.25-15) compared with children with CHD without OSA (median total errors, 2, IQR, 1-8; P = .02).
interpretationChildren with CHD and comorbid OSA have impaired neurocognition compared with children with CHD without comorbid OSA. OSA may be a reversible cause of neurocognitive impairment in children with CHD. Further research is needed to evaluate the effects of OSA treatment on neurocognitive impairment in children with CHD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.