Evidence map›Paper›PMID 32222086›Full record

ArticleJournal of labelled compounds & radiopharmaceuticals2020

Arabinofuranose-derived positron-emission tomography radiotracers for detection of pathogenic microorganisms.

Mausam Kalita, Matthew F L Parker, Justin M Luu, Megan N Stewart, Joseph E Blecha, Henry F VanBrocklin, Michael J Evans, Robert R Flavell, Oren S Rosenberg, Michael A Ohliger and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of labelled compounds & radiopharmaceuticals, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mausam KalitaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Matthew F L ParkerDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Justin M LuuDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Megan N StewartDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Joseph E BlechaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Henry F VanBrocklinDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.ORCID 0000-0003-2849-0841
Michael J EvansDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Robert R FlavellDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Oren S RosenbergDepartment of Medicine, University of California San Francisco, San Francisco, California.
Michael A OhligerDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.ORCID 0000-0002-1095-046X
University of California, San Francisco · USSan Francisco General Hospital · US

Funding

Development of 11C-PABA as a bacteria-specific imaging agent for spinal infectionsR01EB025985 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAIN, SANJAY, WILSON, DAVID M · 2018 to 2021
$2.7M
Clinical translation of D-amino acid derived PET tracers for imaging spinalinfectionR01EB024014 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OHLIGER, MICHAEL, WILSON, DAVID M · 2017 to 2020
$2.2M
NIBIB NIH HHS R01 EB024014NIBIB NIH HHS R01 EB025985U.S. Department of Defense DOD A132172
6 · The paper itself

Abstract

purposeDetection of bacteria-specific metabolism via positron emission tomography (PET) is an emerging strategy to image human pathogens, with dramatic implications for clinical practice. In silico and in vitro screening tools have recently been applied to this problem, with several monosaccharides including l-arabinose showing rapid accumulation in Escherichia coli and other organisms. Our goal for this study was to evaluate several synthetically viable arabinofuranose-derived PROCEDURES: We synthesized four radiolabeled arabinofuranose-derived sugars: 2-deoxy-2-[

resultsAll

conclusionsArabinofuranose-derived

Indexed as

ArabinoseEscherichia coliPositron-Emission TomographyRadiopharmaceuticalsarabinofuranoseArabinoseRadiopharmaceuticalsarabinofuranoseimaginginfectionpositron emission tomographysugars

Identifiers

PMID32222086
PMCPMC7364301
OpenAlexW3013239298

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.