Evidence map›Paper›PMID 32221851›Full record

ArticleNeurotoxicity research2021

Effects of L-Serine Against Cisplatin-Mediated Reactive Oxygen Species Generation in Zebrafish Vestibular Tissue Culture and HEI-OC1 Auditory Hybridoma Cells.

Jerry D Monroe, Satya A Moolani, Elvin N Irihamye, Alexandra M Johnston, Michael E Smith

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. L-serine metabolic regulation and host respiratory homeostasis.Frontiers in cellular and infection microbiology · 2025
    Review
  2. Hair cell toxicology: With the help of a little fish.Frontiers in cell and developmental biology · 2022
    Review
  3. BMAA, Neurodegeneration, and Neuroprotection.Neurotoxicity research · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jerry D MonroeBiology Department, Western Kentucky University, Bowling Green, KY, 42101-1080, USA.
Satya A MoolaniBiology Department, Western Kentucky University, Bowling Green, KY, 42101-1080, USA.
Elvin N IrihamyeBiology Department, Western Kentucky University, Bowling Green, KY, 42101-1080, USA.
Alexandra M JohnstonBiology Department, Western Kentucky University, Bowling Green, KY, 42101-1080, USA.
Michael E SmithBiology Department, Western Kentucky University, Bowling Green, KY, 42101-1080, USA. michael.smith1@wku.edu.
Western Kentucky University · US

Funding

Finding novel platinum(II) complex anti-cancer drugs with reduced ototoxicityR15CA188890 · NCI · WESTERN KENTUCKY UNIVERSITY · PI SMITH, MICHAEL E, WILLIAMS, KEVIN M · 2015 to 2015
$414k
NCI NIH HHS T1 R15 CA188890-01A1NIH HHS 2 P20 GM103436-19Western Kentucky University Gatton Academy of Mathematics and Science Summer Research Internship Grant
6 · The paper itself

Abstract

Cisplatin is a platinum-based chemotherapy compound effective against a variety of cancers. However, it can cause increased reactive oxygen species (ROS) production in auditory and vestibular tissue leading to permanent hearing and balance loss. The amino acid, L-serine, has been shown to reduce ROS in some tissue types. In this project, we first investigated whether L-serine could reduce cisplatin-mediated ROS generation in zebrafish utricular tissue culture using spectrophotometry and the fluorescent ROS detector dye, H

Indexed as

AnimalsCell Line, TumorCisplatinFemaleHybridomasMaleReactive Oxygen SpeciesSaccule and UtricleSerineTissue Culture TechniquesZebrafishCisplatinReactive Oxygen SpeciesSerineCisplatinHEI-OC1 cellsL-serineOtotoxicityReactive oxygen speciesZebrafish tissue culture

Identifiers

PMID32221851
OpenAlexW3013470165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.