SynthesisInternational journal of clinical oncology2020
Salivary metabolites to detect patients with cancer: a systematic review.
Synthesis in International journal of clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Non-invasive detection and monitoring of oral squamous cell carcinoma and oral potentially malignant disorders: an umbrella review on diagnostic accuracy.Clinical oral investigations · 2026Pooled it
- Salivary metabolites for pancreatic cancer diagnosis: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Diagnostic Accuracy of Liquid Biopsy for Oral Potentially Malignant Disorders and Head and Neck Cancer: an Overview of Systematic Reviews.Current oncology reports · 2023Pooled it
- Salivary biomarkers in breast cancer diagnosis: A systematic review and diagnostic meta-analysis.Cancer medicine · 2022Pooled it
- Salivary metabolomics for the diagnosis of periodontal diseases: a systematic review with methodological quality assessment.Metabolomics : Official journal of the Metabolomic Society · 2021Pooled it
- Systematic verification of saliva-based biosignatures for oral cancer via targeted metabolomics.Journal of food and drug analysis · 2026Article
- Impact of Selected Pre-Analytical and Analytical Factors on Untargeted Salivary Metabolomics.International journal of molecular sciences · 2026Article
- From gut to mouth: salivary signatures of carcinogenic microbiota.Frontiers in cellular and infection microbiology · 2026Review
- Review
- SERS-AI-LUA-Driven Salivary Diagnosis of Head and Neck Cancer Using Graphene-Assisted Plasmonic Nanocorals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Emerging salivary biomarkers for early detection of oral squamous cell carcinoma.World journal of clinical oncology · 2025Review
- Factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disorders.Frontiers in oral health · 2024Article
- Causal associations of histidine and 12 site-specific cancers: a bidirectional Mendelian randomization study.Molecular genetics and genomics : MGG · 2023Article
- Potential Diagnostic Value of Salivary Tumor Markers in Breast, Lung and Ovarian Cancer: A Preliminary Study.Current issues in molecular biology · 2023Article
- Oral Sources of Salivary Metabolites.Metabolites · 2023Review
- Article
- «Salivaomics» of Different Molecular Biological Subtypes of Breast Cancer.Current issues in molecular biology · 2022Article
- Potential Diagnostic Significance of Salivary Copper Determination in Breast Cancer Patients: A Pilot Study.Biological trace element research · 2022Article
- Oral Cancer Screening: Past, Present, and Future.Journal of dental research · 2021Review
- Aging-Related Metabolic Dysfunction in the Salivary Gland: A Review of the Literature.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Novel adjunctive screening aids are needed to reduce the morbidity and mortality related to cancer, and every effort should be made for early diagnosis. This systematic review aimed to evaluate salivary metabolites and their diagnostic value in patients with cancer.The systematic review was performed in two phases and included studies that focused on the diagnostic value of salivary metabolites in humans with solid malignant neoplasms. Five electronic databases were searched, and the risk of bias in individual studies was evaluated using the revised Quality Assessment of Diagnostic Accuracy Studies criteria (QUADAS-2). All procedures were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.Of the 1151 studies retrieved, 25 were included; 13 studies used targeted and 12 untargeted metabolomics approaches. Most studies included patients with breast and oral cancer. Except for one, all studies had case-control designs, and none fulfilled all quality assessments. Overall, 140 salivary metabolites were described. The most frequently reported metabolites were alanine, valine, and leucine. Among the 11 studies that reported diagnostic test accuracy (DTA) values, proline, threonine, and histidine in combination and monoacylglycerol alone demonstrated the highest DTA for breast cancer. Combined choline, betaine, pipecolinic acid, and L-carnitine showed better discriminatory performance for early oral cancer.This systematic review highlights the current evidence on salivary metabolites that may be used as a future strategy to diagnose cancer. Further studies including larger sample sizes with confirmation of the results by untargeted analysis are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.