Evidence map›Paper›PMID 32221745›Full record

ArticleJournal of cancer research and clinical oncology2020

Pregnancy, time to pregnancy and obstetric outcomes among female childhood cancer survivors: results of the DCOG LATER-VEVO study.

M van Dijk, F E van Leeuwen, A Overbeek, C B Lambalk, M M van den Heuvel-Eibrink, W van Dorp, W J Tissing, L C Kremer, J J Loonen, B Versluys and 7 more

Open access · hybridAbstract readClinical StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

M van DijkDepartment of Paediatric Oncology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands. marloes.vandijk@amsterdamumc.nl.
F E van LeeuwenDepartment of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
A OverbeekDepartment of Paediatric Oncology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.
C B LambalkDepartment of Obstetrics and Gynaecology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
M M van den Heuvel-EibrinkPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
W van DorpDepartment of Gynaecology and Obstetrics, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, The Netherlands.
W J TissingPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
L C KremerPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
J J LoonenDepartment of Haematology, Radboud University Medical Center, Nijmegen, The Netherlands.
B VersluysPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
D BrestersPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
C M RonckersPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
H J van der PalPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
C C M BeerendonkDepartment of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The Netherlands.
G J L KaspersDepartment of Paediatric Oncology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.
E van Dulmen-den BroederDepartment of Paediatric Oncology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.
M H van den BergDepartment of Paediatric Oncology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.
Princess Máxima Center · NLVrije Universiteit Amsterdam · NLRadboud University Nijmegen · NLAmsterdam University Medical Centers · NLEmma Kinderziekenhuis · NLErasmus MC · NLOncode Institute · NL

Funding

KWF Kankerbestrijding (NL) VU 2006-3622Stichting Kinderen Kankervrij (NL) 20
6 · The paper itself

Abstract

purposeTo evaluate pregnancy rates, time to pregnancy (TTP) and obstetric outcomes in female childhood cancer survivors (CCSs) and to identify specific diagnosis- and treatment-related factors associated with these outcomes.

methodsThe study is part of the DCOG LATER-VEVO study, a nationwide multicenter cohort study evaluating fertility among long-term Dutch female CCSs. Data were collected by questionnaire. The current study included 1095 CCSs and 812 controls, consisting of sisters of CCSs and a random sample of women from the general population.

resultsAmong the subgroup of women who ever had the desire to become pregnant, the chance of becoming pregnant was significantly lower for CCSs than controls (OR 0.5, 95%CI 0.4-0.8). Moreover, TTP was 1.1 times longer for CCSs compared to controls (p = 0.09) and was significantly longer in survivors of CNS and renal tumours. Overall, no differences were found between CCSs and controls regarding the probability of ever having had a miscarriage, still birth, or induced abortion. However, CCSs had a significantly increased risk of delivering preterm (OR 2.2, 95%CI 1.3-3.7) and delivering via caesarean section (OR 1.8, 95%CI 1.2-2.6). Treatment with lower abdominal/pelvic radiotherapy was strongly associated with several adverse obstetric outcomes.

conclusionCCSs are less likely to have ever been pregnant. Among those who do become pregnant, certain subgroups of CCSs are at increased risk of longer TTP. Moreover, as pregnant CCSs, especially those treated with lower abdominal/pelvic radiotherapy, are more likely to develop various adverse obstetric outcomes, appropriate obstetric care is highly advocated.

Indexed as

Cancer SurvivorsAdultCase-Control StudiesChildCohort StudiesFemaleHumansNeoplasmsNetherlandsPregnancyPregnancy OutcomePregnancy RateTime FactorsYoung AdultChildhood cancer survivorsObstetric outcomesPregnancy ratesTime to pregnancy

Identifiers

PMID32221745
PMCPMC7230041
OpenAlexW3013910396

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.