ReviewEuropean journal of epidemiology2020
Applying the exposome concept in birth cohort research: a review of statistical approaches.
Review in European journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identifying Key Predictors of Mid-Childhood Obesity in a Population-Based Cohort Study: An Evidence Synthesis and Predictive Modeling Study.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Relevance and challenges of exposome studies for environmental health research.Environmental health : a global access science source · 2026Review
- Advanced Bayesian kernel machine regression for large-scale exposome studies: Making the impossible possible.Innovation (Cambridge (Mass.)) · 2026Article
- Multilevel predictors of ultra-processed food intake in Canadian preschoolers.Communications medicine · 2026Article
- RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood.Genome biology · 2025Article
- Social determinants impact both viral infections and brain development.Pediatric research · 2025Review
- A Bayesian life-course linear structural equations model (BLSEM) to explore the development of body mass index (BMI) from the prenatal stage until middle age.International journal of obesity (2005) · 2025Article
- Estimating the causal effects of exposure mixtures: a generalized propensity score method.BMC medical research methodology · 2025Article
- Using mixture and exposome methods to assess the associations and interactions of chemical biomarkers with semen parameters.Environment international · 2025Article
- Global research trends on the human exposome: a bibliometric analysis (2005-2024).Environmental science and pollution research international · 2025Review
- Article
- Leveraging Administrative Health Databases to Address Health Challenges in Farming Populations: Scoping Review and Bibliometric Analysis (1975-2024).JMIR public health and surveillance · 2025Article
- Association of obesogenic environment and hedonic appetite with chronic fatigue in Turkish adults.Frontiers in nutrition · 2025Article
- The Effects of Environmental Factors on General Human Health: A Scoping Review.Healthcare (Basel, Switzerland) · 2024Article
- Advancing Understanding of Childhood Asthma: Lessons Learned from Birth Cohort Studies.Clinical reviews in allergy & immunology · 2024Review
- Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood.JACC. Advances · 2024Article
- Exploring the link between the pediatric exposome, respiratory health, and executive function in children: a narrative review.Frontiers in public health · 2024Review
- Beyond the single-outcome approach: A comparison of outcome-wide analysis methods for exposome research.Environment international · 2023Article
- Seminar: Scalable Preprocessing Tools for Exposomic Data Analysis.Environmental health perspectives · 2023Article
- Statistical Approaches to Study Exposome-Health Associations in the Context of Repeated Exposure Data: A Simulation Study.Environmental science & technology · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The exposome represents the totality of life course environmental exposures (including lifestyle and other non-genetic factors), from the prenatal period onwards. This holistic concept of exposure provides a new framework to advance the understanding of complex and multifactorial diseases. Prospective pregnancy and birth cohort studies provide a unique opportunity for exposome research as they are able to capture, from prenatal life onwards, both the external (including lifestyle, chemical, social and wider community-level exposures) and the internal (including inflammation, metabolism, epigenetics, and gut microbiota) domains of the exposome. In this paper, we describe the steps required for applying an exposome approach, describe the main strengths and limitations of different statistical approaches and discuss their challenges, with the aim to provide guidance for methodological choices in the analysis of exposome data in birth cohort studies. An exposome approach implies selecting, pre-processing, describing and analyzing a large set of exposures. Several statistical methods are currently available to assess exposome-health associations, which differ in terms of research question that can be answered, of balance between sensitivity and false discovery proportion, and between computational complexity and simplicity (parsimony). Assessing the association between many exposures and health still raises many exposure assessment issues and statistical challenges. The exposome favors a holistic approach of environmental influences on health, which is likely to allow a more complete understanding of disease etiology.
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Registered trials
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