Evidence map›Paper›PMID 32221654›Full record

Trial reportEuropean archives of psychiatry and clinical neuroscience2021

Cognitive outcomes of the bipolar depression electrical treatment trial (BETTER): a randomized, double-blind, sham-controlled study.

Gabriel Tortella, Bernardo Sampaio-Junior, Marina L Moreno, Adriano H Moffa, Adriano Fernandes da Silva, Beny Lafer, Paulo Andrade Lotufo, Wagner Gattaz, Lucas Borrione, Rodrigo Machado-Vieira and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European archives of psychiatry and clinical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02152878 (Transcranial Direct Current Stimulation for the Treatment of Bipolar Depression), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02152878 phase2 / phase3completednot on this map

Transcranial Direct Current Stimulation for the Treatment of Bipolar Depression

TypeinterventionalSponsorUniversity of Sao PauloRan2014 to 2016Enrolled60ConditionsDepression, BipolarArmsSham stimulation, Active stimulation
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Gabriel TortellaDepartment of Internal Medicine, Faculdade de Medicina da Universidade de São Paulo and Hospital Universitário, Universidade de São Paulo, Av. Prof Lineu Prestes 2565, São Paulo, 05508-000, Brazil.
Bernardo Sampaio-JuniorPrivate Practice, São Paulo, Brazil.
Marina L MorenoPrivate Practice, São Paulo, Brazil.
Adriano H MoffaSchool of Psychiatry, Black Dog Institute, University of New South Wales, Hospital Rd, Randwick, Sydney, NSW, 2031, Australia.
Adriano Fernandes da SilvaPrivate Practice, São Paulo, Brazil.
Beny LaferBipolar Disorder Research Program, Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
Paulo Andrade LotufoDepartment of Internal Medicine, Faculdade de Medicina da Universidade de São Paulo and Hospital Universitário, Universidade de São Paulo, Av. Prof Lineu Prestes 2565, São Paulo, 05508-000, Brazil.
Wagner GattazService of Interdisciplinary Neuromodulation, Instituto de Psiquiatria, Laboratory of Neurosciences (LIM-27)Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBioN), Department and Institute of Psychiatry, Faculdade de Medicina da Universidade de São Paulo, R Dr Ovidio Pires de Campos 785, 2o andar, São Paulo, 05403-000, Brazil.
Lucas BorrioneService of Interdisciplinary Neuromodulation, Instituto de Psiquiatria, Laboratory of Neurosciences (LIM-27)Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBioN), Department and Institute of Psychiatry, Faculdade de Medicina da Universidade de São Paulo, R Dr Ovidio Pires de Campos 785, 2o andar, São Paulo, 05403-000, Brazil.
Rodrigo Machado-VieiraDepartment of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Science Center, Houston, TX, USA.
Stephan GoerigkDepartment of Psychological Methodological and Assessment, Ludwig-Maximilians-University, Munich, Germany.
Isabela M BenseñorDepartment of Internal Medicine, Faculdade de Medicina da Universidade de São Paulo and Hospital Universitário, Universidade de São Paulo, Av. Prof Lineu Prestes 2565, São Paulo, 05508-000, Brazil.
Andre R BrunoniDepartment of Internal Medicine, Faculdade de Medicina da Universidade de São Paulo and Hospital Universitário, Universidade de São Paulo, Av. Prof Lineu Prestes 2565, São Paulo, 05508-000, Brazil. brunoni@usp.br.ORCID http://orcid.org/0000-0002-6310-3571
Universidade de São Paulo · BRBlack Dog Institute · AUHochschule Fresenius · DEThe University of Texas Health Science Center at Houston · US

Funding

Research Training in Geriatrics and GerontologyT32AG020493 · NIA · UNIVERSITY OF ROCHESTER · PI HALL, WILLIAM JOHN · 2005 to 2009
$1.2M
Fundação de Amparo à Pesquisa do Estado de São Paulo 12/20911-5National Alliance for Research on Schizophrenia and Depression 13/20493
6 · The paper itself

Abstract

Bipolar depression is associated with marked cognitive deficits. Pharmacological treatments for this condition are limited and may aggravate depressive and cognitive symptoms. Therefore, therapeutic interventions that preserve adequate cognitive functioning are necessary. Our previous results demonstrated significant clinical efficacy of transcranial direct current stimulation (tDCS) in the Bipolar Depression Electrical Treatment Trial (BETTER). Here, cognitive outcomes of this study are reported. We randomized 59 patients with bipolar disorder I or II in an acute depressive episode to receive active (12 2 mA, 30-min, anodal-left, cathodal-right prefrontal cortex tDCS sessions) or sham tDCS. Patients were on stable pharmacological regimen for at least 2 weeks. A battery of 12 neuropsychological assessments in five cognitive domains (attention and processing speed, memory, language, inhibitory control, and working memory and executive function) was performed at baseline, after two weeks and at endpoint (week 6). No significant differences between groups over 6 weeks of treatment were observed for any cognitive outcomes. Moreover, no decrease in cognitive performance was observed. Our findings warrant further replication in larger studies. Trial Registration: clinicaltrials.gov Identifier: NCT02152878.

Indexed as

CognitionTranscranial Direct Current StimulationAdolescentAdultAgedBipolar DisorderDepressionDouble-Blind MethodFemaleHumansMaleMiddle AgedPrefrontal CortexTreatment OutcomeYoung AdultBipolar disorderClinical trialMental illnessNon-invasive brain stimulationPsychiatryTranscranial direct current stimulation

Identifiers

PMID32221654
OpenAlexW3013607656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.