Evidence map›Paper›PMID 32221652›Full record

Trial reportAnnals of hematology2020

Elevated serum myoglobin levels at hospital admission and the risk of early death among patients with hemophagocytic lymphohistiocytosis: evidence from 155 pediatric patients.

Xun Li, Haipeng Yan, Xinping Zhang, Jiaotian Huang, Shi-Ting Xiang, Zhenya Yao, Ping Zang, Desheng Zhu, Zhenghui Xiao, Xiulan Lu

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Annals of hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xun Li *Pediatrics Research Institute of Hunan Province, Hunan Children's Hospital, University of South China, Changsha, China.
Haipeng Yan *Department of Pediatric Intensive Care Unit, Hunan Children's Hospital, University of South China, Changsha, China.
Xinping ZhangDepartment of Pediatric Intensive Care Unit, Hunan Children's Hospital, University of South China, Changsha, China.
Jiaotian HuangDepartment of Pediatric Intensive Care Unit, Hunan Children's Hospital, University of South China, Changsha, China.
Shi-Ting XiangPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, University of South China, Changsha, China.
Zhenya YaoDepartment of Pediatric Intensive Care Unit, Hunan Children's Hospital, University of South China, Changsha, China.
Ping ZangDepartment of Pediatric Intensive Care Unit, Hunan Children's Hospital, University of South China, Changsha, China.
Desheng ZhuDepartment of Pediatric Intensive Care Unit, Hunan Children's Hospital, University of South China, Changsha, China.
Zhenghui XiaoDepartment of Pediatric Intensive Care Unit, Hunan Children's Hospital, University of South China, Changsha, China. xiaozh888@126.com.
Xiulan LuDepartment of Pediatric Intensive Care Unit, Hunan Children's Hospital, University of South China, Changsha, China. 13787252674@163.com.
University of South China · CNHunan Children's Hospital · CN

Funding

The Key Laboratory of Emergency Medicine for Children NAThe Ministry of Science and Technology in Hunan Provincial of China 2018TP1028The Pediatric Critical Care Center of Hunan Key Construction Specialty NAThe Science & Technology Project of Hunan Province 2018SK2135
6 · The paper itself

Abstract

Patients with hemophagocytic lymphohistiocytosis (HLH) have high risk of early mortality. The purpose of this study was to test the hypothesis that the elevated level of serum myoglobin among patients with HLH is associated with disease severity and increased risk of mortality. We retrospectively investigated the serum myoglobin levels from 155 pediatric patients diagnosed with HLH in the Hunan Children's Hospital, China. The levels of myoglobin and creatine kinase at hospital admission among non-survivors and survivors were compared. The myoglobin level was dichotomized for the estimation of hazard ratio (HR) for mortality. Patients who died within 7 and 30 days of hospitalization had significantly higher myoglobin levels than did survivors (p < 0.05). The myoglobin level was negatively associated with the days of survival among non-survivors (Spearman correlation coefficient = - 0.29, p = 0.04). An elevated myoglobin level (> 90 ng/mL) was significantly associated with increased mortality (unadjusted HR = 2.66, 95%CI: 1.41, 5.00, p = 0.0024) and persisted after adjusting for age, Epstein-Barr virus infection, admission department, acute kidney injury, myocardial damage, and shock. In conclusion, an elevated serum myoglobin level was associated with increased risk of early death among pediatric patients with HLH, suggesting the potential of myoglobin to be used as a reference indicator for monitoring and managing of HLH.

Indexed as

Patient AdmissionBiomarkersChildChild, PreschoolDisease-Free SurvivalFemaleHumansInfantInfant, NewbornLymphohistiocytosis, HemophagocyticMaleMyoglobinSurvival RateBiomarkersMyoglobinCreatine kinaseHemophagocytic lymphohistiocytosisMortalityMyoglobinPrognostic factor

Identifiers

PMID32221652
OpenAlexW3013239342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.