ArticleThe Journal of nutrition2020
Prepregnancy Obesity Is Not Associated with Iron Utilization during the Third Trimester.
Article in The Journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis.Scientific reports · 2021Pooled it
- Maternal Adiposity and Inflammation: Risk Factors for Iron Deficiency in Pregnancy.The Journal of nutrition · 2025Trial
- Maternal iron kinetics and maternal-fetal iron transfer in normal-weight and overweight pregnancy.The American journal of clinical nutrition · 2022Trial
- Maternal Overweight and Obesity during Pregnancy Are Associated with Neonatal, but Not Maternal, Hepcidin Concentrations.The Journal of nutrition · 2021Trial
- Dietary Interventions Targeting Maternal Obesity: Intergenerational Effects, Mechanisms, and Translational Insights.Current nutrition reports · 2026Review
- Is BMI a Useful Indicator of Prenatal Health Among Black American Women?Journal of racial and ethnic health disparities · 2024Article
- Hepcidin across pregnancy and its correlation with maternal markers of iron and inflammation, maternal body weight outcomes, and offspring neurodevelopmental outcomes: a systematic review and meta-analysis.AJOG global reports · 2023Review
- Fetal iron uptake from recent maternal diet and the maternal RBC iron pool.The American journal of clinical nutrition · 2022Article
- Recruitment and Retention of Urban Pregnant Women to a Clinical Study Administering an Oral Isotope Dietary Tracer.Women's health reports (New Rochelle, N.Y.) · 2022Article
- Association of Pregestational BMI and Gestational Weight Gain with Maternal and Neonatal Outcomes in Adolescents and Adults from Mexico City.International journal of environmental research and public health · 2021Observational
- Prepregnancy Obesity Does Not Impact Placental Iron Trafficking.The Journal of nutrition · 2021Article
- Are Pregnant Women Who Are Living with Overweight or Obesity at Greater Risk of Developing Iron Deficiency/Anaemia?Nutrients · 2021Review
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Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAn adequate maternal iron supply is crucial for maternal red blood cell (RBC) expansion, placental and fetal growth, and fetal brain development. Obese women may be at risk for poor iron status in pregnancy due to proinflammatory-driven overexpression of hepcidin leading to decreased iron bioavailability.
objectiveThe objective of this study was to determine the impact of prepregnancy (PP) obesity on third-trimester maternal iron utilization.
designUsing the stable isotope 57Fe, we measured iron utilization in the third trimester in PP obese [BMI (in kg/m2): ≥30] and nonobese (BMI: 18.5-29.9) women. We also assessed iron status, hepcidin, inflammation, erythropoietin, dietary iron intake, and gestational weight gain. Descriptive and inferential statistical tests (e.g., Student t test, Pearson correlation) were used for data analysis.
resultsFifty pregnant women (21 PP obese, 29 PP nonobese) were included. Mean age was 27.6 ± 6.8 y and mean gestational age at time of 57Fe administration was 32.7 ± 0.7 wk. Anemia (hemoglobin <11 g/dL for non-black and <10.2 g/dL for black women) affected 38% of women (43% PP obese compared with 35% PP nonobese; P = 0.55). Women with PP obesity had significantly higher C-reactive protein (8.5 compared with 3.4 mg/L, P = 0.0007) and total body iron corrected for inflammation (6.0 compared with 4.3 mg/kg, P = 0.04) compared with the nonobese women. There was no difference in serum hepcidin or iron utilization between the PP BMI groups.
conclusionThis is the first study to assess the impact of PP obesity on maternal iron utilization. We found no difference in iron utilization in the third trimester of pregnancy in women with and without PP obesity. Despite higher frequency of anemia, women with PP obesity had less depleted body iron stores, suggesting some degree of iron sequestration. This finding should be followed up and extended to understand effects on fetal iron bioavailability.
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