Evidence map›Paper›PMID 32221498›Full record

ArticleNature chemistry2020

Multi-responsive hydrogel structures from patterned droplet networks.

Florence G Downs, David J Lunn, Michael J Booth, Joshua B Sauer, William J Ramsay, R George Klemperer, Craig J Hawker, Hagan Bayley

Abstract read
In one paragraph

Article in Nature chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. The Ion Permeability of DNA Nanotube Channels.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
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  4. Review
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  7. Harnessing Phase Separation for the Development of High-Performance Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. A Photonastic Prototissue Capable of Photo-Mechano-Chemical Transduction.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Mechanical and Light Activation of Materials for Chemical Production.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  18. Article
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Florence G DownsDepartment of Chemistry, University of Oxford, Oxford, UK.
David J LunnDepartment of Chemistry, University of Oxford, Oxford, UK. davidjlunn@mrl.ucsb.edu.ORCID http://orcid.org/0000-0002-0211-3581
Michael J BoothDepartment of Chemistry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4224-798X
Joshua B SauerDepartment of Chemistry, University of Oxford, Oxford, UK.
William J RamsayDepartment of Chemistry, University of Oxford, Oxford, UK.
R George KlempererDepartment of Chemistry, University of Oxford, Oxford, UK.
Craig J HawkerMaterials Research Laboratory, University of California Santa Barbara, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0001-9951-851X
Hagan BayleyDepartment of Chemistry, University of Oxford, Oxford, UK. hagan.bayley@chem.ox.ac.uk.ORCID http://orcid.org/0000-0003-2499-6116

Funding

Biotechnology and Biological Sciences Research Council BB/M011224/1European Research Council 294443
6 · The paper itself

Abstract

Responsive hydrogels that undergo controlled shape changes in response to a range of stimuli are of interest for microscale soft robotic and biomedical devices. However, these applications require fabrication methods capable of preparing complex, heterogeneous materials. Here we report a new approach for making patterned, multi-material and multi-responsive hydrogels, on a micrometre to millimetre scale. Nanolitre aqueous pre-gel droplets were connected through lipid bilayers in predetermined architectures and photopolymerized to yield continuous hydrogel structures. By using this droplet network technology to pattern domains containing temperature-responsive or non-responsive hydrogels, structures that undergo reversible curling were produced. Through patterning of gold nanoparticle-containing domains into the hydrogels, light-activated shape change was achieved, while domains bearing magnetic particles allowed movement of the structures in a magnetic field. To highlight our technique, we generated a multi-responsive hydrogel that, at one temperature, could be moved through a constriction under a magnetic field and, at a second temperature, could grip and transport a cargo.

Identifiers

PMID32221498
PMCPMC7117959

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.