ArticleNature communications2020
Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
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Who cites it
46 citing papers in PubMed, 103 citations in OpenAlex.
- BmADARa cooperatively inhibits BmNPV proliferation through the interaction of its dsRBD2 with BmDcr-2-DEXHc in silkworm, Bombyx mori.Insect science · 2026Article
- A-to-I mRNA editing: Why not simply incorporate inosine during mRNA synthesis?Molecular biology reports · 2026Review
- ADARs mediate distinct RNA editing activity and gene regulation in theRNA (New York, N.Y.) · 2026Article
- Article
- The Landscape and Regulatory Determinants of A-to-I RNA Editing in Escherichia coli and Pseudomonas aeruginosa Isolated From Patients With Urinary Tract and Ear Infections.The Journal of infectious diseases · 2026Article
- Abundant A-to-I RNA editing in spermatocytes may suppress transposons to compensate for piRNA downregulation in male germlines.RNA biology · 2025Article
- ADARs mediate distinct RNA editing activity and gene regulation in thebioRxiv : the preprint server for biology · 2025Article
- The kinase GSK-3 alters the RNA-binding protein landscape of lipid metabolism transcripts leading to altered expression in the C. elegans nervous system.Nucleic acids research · 2025Article
- Adar contributes to genome integrity by regulating R-loop homeostasis in Drosophila.BMC biology · 2025Article
- ADARs: pleiotropy in function, versatility in application.Nucleic acids research · 2025Review
- A-to-I mRNA editing recodes hundreds of genes in dozens of species and produces endogenous protein isoforms in bacteria.Nucleic acids research · 2025Article
- A-to-I mRNA editing in bacteria can affect protein sequence, disulfide bond formation, and function.Nucleic acids research · 2025Article
- Computer-Aided Discovery of Natural Compounds Targeting the ADAR2 dsRBD2-RNA Interface and Computational Modeling of Full-Length ADAR2 Protein Structure.International journal of molecular sciences · 2025Article
- A-to-I RNA editing ofeLife · 2025Article
- Neuronal expressions of Taxi and Adar are crucial in maintaining the lifespan ofJournal of genetics · 2025Article
- Deciphering the mechanistic roles of ADARs in cancer pathogenesis, tumor immune evasion, and drug resistance.Frontiers in immunology · 2025Review
- DsRNA as pathogen-associated molecular pattern in innate immunity and multiple functions of the RNAi machinery complicate the use of RNAi in pest control.Frontiers in insect science · 2025Review
- Host response to Aplysia Abyssovirus 1 in nervous system and gill.Developmental and comparative immunology · 2024Article
- A highly conserved A-to-I RNA editing event within the glutamate-gated chloride channel GluClα is necessary for olfactory-based behaviors inScience advances · 2024Article
- Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 4 countries.
Patricia Deng *Department of Genetics, Stanford University, Stanford, CA, USA.
Anzer Khan *Central European Institute of Technology, Masaryk University, Brno, Czech Republic.ORCID http://orcid.org/0000-0002-8024-5547
Dionna JacobsonDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6568-7136
Nagraj SambraniCentral European Institute of Technology, Masaryk University, Brno, Czech Republic.ORCID http://orcid.org/0000-0001-5956-5725
Leeanne McGurkMRC Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0002-6493-6751
Xianghua LiMRC Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0002-2172-7271
Aswathy JayasreeCentral European Institute of Technology, Masaryk University, Brno, Czech Republic.
Jan HejatkoCentral European Institute of Technology, Masaryk University, Brno, Czech Republic.
Galit Shohat-OphirThe Faculty of Life Sciences and The Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel.
Mary A O'ConnellCentral European Institute of Technology, Masaryk University, Brno, Czech Republic.
Jin Billy LiDepartment of Genetics, Stanford University, Stanford, CA, USA. jin.billy.li@stanford.edu.ORCID http://orcid.org/0000-0003-0713-1399
Liam P KeeganCentral European Institute of Technology, Masaryk University, Brno, Czech Republic. Liam.Keegan@ceitec.muni.cz.
Central European Institute of Technology · CZStanford University · USWestern General Hospital · GBBar-Ilan University · IL
Funding
Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9MINSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2MProfiling and Dissecting the Dynamic Regulation of RNA EditingR01GM102484 · NIGMS · STANFORD UNIVERSITY · PI LI, JIN BILLY · 2013 to 2021
$3.1MSystematic characterization of trans regulation of A-to-I RNA editing in neuronsR01MH115080 · NIMH · STANFORD UNIVERSITY · PI LI, JIN BILLY · 2017 to 2021
$2.3MSystematic approaches to deciphering cis regulation of A-to-I RNA editingR01GM124215 · NIGMS · STANFORD UNIVERSITY · PI LI, JIN BILLY · 2017 to 2020
$1.7MCOMPUTATIONAL METHODS FOR PROTEOMIC ANALYSISK22HG000044 · NHGRI · UNIVERSITY OF UTAH · PI GIDDINGS, MORGAN CORINNE · 2000 to 2005
$1.3MMedical Research Council U.1275.01.005.00001.01NHGRI NIH HHS K22 HG000044NHGRI NIH HHS T32 HG000044NIGMS NIH HHS R01 GM102484NIGMS NIH HHS R01 GM124215NIGMS NIH HHS T32 GM007276NIMH NIH HHS R01 MH115080
Abstract
ADAR RNA editing enzymes are high-affinity dsRNA-binding proteins that deaminate adenosines to inosines in pre-mRNA hairpins and also exert editing-independent effects. We generated a Drosophila Adar
Indexed as
Adenosine DeaminaseAdenosine MonophosphateAgingAnimalsBrainCatalysisDrosophila melanogasterDrosophila ProteinsGene Expression RegulationImmunity, InnateLocomotionNerve DegenerationPoint MutationProtein DomainsRibonuclease IIIRNA EditingAdar protein, DrosophilaAdenosine DeaminaseAdenosine MonophosphateDCR-2 protein, DrosophilaDrosophila ProteinsRibonuclease IIIRNA HelicasesRNA, Messenger
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