ArticleThe American journal of case reports2020
SMART (Stroke-Like Migraine Attacks After Radiation Therapy) Syndrome: A Case Study with Imaging Supporting the Theory of Vascular Dysfunction.
Article in The American journal of case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Neurological Puzzles After Radiotherapy: Mysterious Clues of Smart Syndrome, Two Case Reports.Journal of clinical ultrasound : JCU · 2026Article
- Chronic Neurological Complications of Brain Tumors and Brain Tumor Treatments.Current neurology and neuroscience reports · 2025Review
- Resolution of Refractory Status Epilepticus With Ketamine Without Intubation in a Patient With Stroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome.Case reports in neurological medicine · 2025Article
- Positron Emission Tomography and Magnetic Resonance Imaging Findings in the Diagnosis of Stroke-Like Migraine Attacks after Radiation Therapy Syndrome: A Case Report.Advances in radiation oncology · 2024Article
- Article
- Unexpected Cerebral Hyperperfusion after Transient Hypoperfusion Associated with Stroke-like Migraine Attacks after Radiation Therapy Syndrome.NMC case report journal · 2024Article
- Comprehensive Update and Review of Clinical and Imaging Features of SMART Syndrome.AJNR. American journal of neuroradiology · 2023Review
- SMART Syndrome: Case Report and Review of the Literature.Journal of the Belgian Society of Radiology · 2023Article
- Prognostic Factors of Stroke-Like Migraine Attacks after Radiation Therapy (SMART) Syndrome.AJNR. American journal of neuroradiology · 2022Article
- Atypical imaging findings of presumed stroke-like migraine attacks after radiation therapy syndrome in the brainstem.Neuroradiology · 2021Article
- Stroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome: A Comprehensive Review.Current pain and headache reports · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND SMART (Stroke-like Migraine Attacks after Radiation Therapy) syndrome is an uncommon delayed complication of cerebral radiotherapy. Less than 50 cases have been reported in the literature since it was first described in 1995. On average, presentation is about 20 years after radiotherapy, and patients commonly present with headaches, complex seizures, and stroke-like symptoms. The exact pathophysiology of the disease remains poorly understood, but one theory suggests radiation-induced vascular dysfunction. CASE REPORT We present one such case of a 28-year-old man who presented to our Emergency Department with a gradually progressive severe headache and right-sided weakness developing over a few hours. MRI played a central role in the diagnosis of SMART syndrome, with serial studies demonstrating and supporting the theory of vascular dysfunction. The condition is usually self-limiting, and most patients achieve complete recovery of symptoms, as did ours. Its optimal management remains unclear. CONCLUSIONS Better understanding of the imaging findings in SMART syndrome may help differentiate it from tumor recurrence, cerebral infections, or vasculitis. Because the diagnosis of this condition portends a significantly better prognosis and substantially alters patient expectation and management, it is important that clinicians are aware of the usual delayed presentation, symptomology, and imaging findings.
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