Evidence map›Paper›PMID 32221065›Full record

SynthesisMedicine2020

Carotid plaque magnetic resonance imaging and recurrent stroke risk: A systematic review and meta-analysis.

Fengbin Deng, Changping Mu, Ling Yang, Huaqinag Li, Xuemei Xiang, Kang Li, Qingjun Yang

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 21 citations in OpenAlex.

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  3. Vascular medicine (London, England) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Fengbin DengRadiology Department, Chongqing General Hospital, University of Chinese Academy of Science.
Changping MuRadiology Department, Chongqing General Hospital, University of Chinese Academy of Science.
Ling YangRadiology Department, Chongqing General Hospital, University of Chinese Academy of Science.
Huaqinag LiRadiology Department, Chongqing General Hospital, University of Chinese Academy of Science.
Xuemei XiangJane lab, Big Data Research Center, University of Electronic Science and Technology of China, China.
Kang LiRadiology Department, Chongqing General Hospital, University of Chinese Academy of Science.
Qingjun YangRadiology Department, Chongqing General Hospital, University of Chinese Academy of Science.
Beijing Institute of Big Data Research · CNS.P.E.C.I.E.S. · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMRI findings of carotid plaque components have been studied recently as a tool to predict recurrent ischemic events. We performed a systematic review and meta-analysis to summarize the association of MRI-determined intraplaque hemorrhage, lipid-rich necrotic core, and thinning/rupture of the fibrous cap with recurrent ischemic events.

methodsElectronic search was performed in PUBMED, EMBASE, Cochrane Controlled Register of Trials (CENTRAL) from inception to Oct 30, 2018. We included cohort studies with an average follow-up time of more than 1 month in which intraplaque hemorrhage, lipid-rich necrotic core, or thinning/rupture of the fibrous cap were associated with recurrent ipsilateral stroke or ischemic events. We performed heterogeneity assessment before carrying out meta-analysis. According to the heterogeneity, we selected fixed-effect model for meta-analysis of the included cohort studies.

resultsUsing a prespecified search strategy, of the 2128 articles, 6 studies with a total number of 621 participants met eligibility for systematic review and meta-analysis. The hazard ratios of intra-plaque hemorrhage, thinning/rupture of the fibrous cap and lipid rich necrotic core as recurrent Stroke/Transient ischemic attack (TIA) were 7.14(95% confidence interval, 4.32 to 11.82), 5.68(95% confidence interval, 2.40 to 13.47), and 2.73(95% confidence interval, 1.04 to 7.16), respectively. No significant heterogeneity was found in the 3 meta-analyses.

conclusionsThe presence of intraplaque hemorrhage, lipid-rich necrotic core, and thinning/rupture of the fibrous cap on MRI of carotid plaque are strong predictors of recurrent stroke events. However, due to the lack of original studies, larger cohort studies are warranted.

Indexed as

Carotid StenosisHemorrhageHumansIschemic Attack, TransientMagnetic Resonance ImagingNecrosisProspective StudiesStroke

Identifiers

PMID32221065
PMCPMC7220511
OpenAlexW3013665591

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.