Evidence map›Paper›PMID 32221037›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

A Critical Role of Formyl Peptide Receptors in Host Defense against

Meihua Zhang, Ji-Liang Gao, Keqiang Chen, Teizo Yoshimura, Weiwei Liang, Wanghua Gong, Xiaoqing Li, Jiaqiang Huang, David H McDermott, Philip M Murphy and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. FPR1-dependent Pro-inflammatory Ccl4Respiratory research · 2025
    Article
  4. Pathogenic and Protective Roles of Neutrophils inPathogens (Basel, Switzerland) · 2025
    Review
  5. TheFrontiers in immunology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Lipopeptide Pepducins as Therapeutic Agents.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  18. Article
  19. Leukocyte chemotactic receptor Fpr1 protects against aging-related posterior subcapsular cataract formation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Meihua ZhangKey Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250002, People's Republic of China.
Ji-Liang GaoLaboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.ORCID 0000-0001-9916-0618
Keqiang ChenCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702.
Teizo YoshimuraDepartment of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.ORCID 0000-0002-3853-2075
Weiwei LiangCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702.
Wanghua GongBasic Research Program, Leidos Biomedical Research, Inc., Frederick, MD 21702.
Xiaoqing LiCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702.
Jiaqiang HuangCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702.
David H McDermottLaboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.ORCID 0000-0001-6978-0867
Philip M MurphyLaboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
Xietong WangKey Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250002, People's Republic of China; wxt65@vip.163.com wangji@mail.nih.gov.
Ji Ming WangCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702; wxt65@vip.163.com wangji@mail.nih.gov.
Frederick National Laboratory for Cancer Research · USNational Institute of Allergy and Infectious Diseases · USShandong University · CNLeidos (United States) · USOkayama University · JPPeking University · CN

Funding

Molecular Analysis Of Leukocyte Activation By ChemoattractantsZIAAI000615 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MURPHY, PHILIP · 2009 to 2025
$44.8M
The Role of Cellular Receptors Involved in Inflammation and Tumor ProgressionZIABC010015 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, JI MING · 2009 to 2023
$6.3M
Role of Formylpeptide Receptors in Host DefenseZIABC010725 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, JI MING · 2009 to 2023
$6.3M
Intramural NIH HHS ZIA BC010725
6 · The paper itself

Abstract

Formyl peptide receptors (FPRs, mouse Fprs) belong to the G protein-coupled receptor superfamily and mediate phagocyte migration in response to bacteria- and host-derived chemoattractants; however, knowledge about their in vivo roles in bacterial pathogenesis is limited. In this study, we investigated the role of Fpr1 and Fpr2 in host defense against

Indexed as

AnimalsBone MarrowCells, CulturedChemotaxisEscherichia coliEscherichia coli InfectionsHEK293 CellsHumansLiverMiceMice, Inbred C57BLMitogen-Activated Protein KinasesNeutrophilsPeritoneal CavityPhagocytosisPhosphorylationMitogen-Activated Protein KinasesReceptors, Formyl Peptide

Identifiers

PMID32221037
PMCPMC8459203
OpenAlexW3013842393

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.