Evidence map›Paper›PMID 32221024›Full record

ArticleNeurology2020

Lipids, apolipoproteins, and prognosis of amyotrophic lateral sclerosis.

Caroline Ingre, Lin Chen, Yiqiang Zhan, Jet Termorshuizen, Li Yin, Fang Fang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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  13. Association between metabolic syndrome, its individual components and progression of amyotrophic lateral sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Caroline IngreFrom the Department of Clinical Neuroscience (C.I.), and Department of Medical Epidemiology and Biostatistics (L.C., Y.Z., J.T., L.Y., F.F.), Karolinska Institutet; and Neurology Clinic (C.I.), Karolinska University Hospital, Stockholm, Sweden.
Lin ChenFrom the Department of Clinical Neuroscience (C.I.), and Department of Medical Epidemiology and Biostatistics (L.C., Y.Z., J.T., L.Y., F.F.), Karolinska Institutet; and Neurology Clinic (C.I.), Karolinska University Hospital, Stockholm, Sweden.
Yiqiang ZhanFrom the Department of Clinical Neuroscience (C.I.), and Department of Medical Epidemiology and Biostatistics (L.C., Y.Z., J.T., L.Y., F.F.), Karolinska Institutet; and Neurology Clinic (C.I.), Karolinska University Hospital, Stockholm, Sweden.
Jet TermorshuizenFrom the Department of Clinical Neuroscience (C.I.), and Department of Medical Epidemiology and Biostatistics (L.C., Y.Z., J.T., L.Y., F.F.), Karolinska Institutet; and Neurology Clinic (C.I.), Karolinska University Hospital, Stockholm, Sweden.
Li YinFrom the Department of Clinical Neuroscience (C.I.), and Department of Medical Epidemiology and Biostatistics (L.C., Y.Z., J.T., L.Y., F.F.), Karolinska Institutet; and Neurology Clinic (C.I.), Karolinska University Hospital, Stockholm, Sweden.
Fang FangFrom the Department of Clinical Neuroscience (C.I.), and Department of Medical Epidemiology and Biostatistics (L.C., Y.Z., J.T., L.Y., F.F.), Karolinska Institutet; and Neurology Clinic (C.I.), Karolinska University Hospital, Stockholm, Sweden. fang.fang@ki.se.ORCID 0000-0002-3310-6456
Karolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine whether lipids and apolipoproteins predict prognosis of patients with amyotrophic lateral sclerosis in a cohort study of 99 patients with amyotrophic lateral sclerosis who were diagnosed during 2015 to 2018 and followed up until October 31, 2018, at the Neurology Clinic in Karolinska University Hospital in Stockholm, Sweden.

methodsTotal cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein AI, apolipoprotein B, and lipid ratios were measured at the time of amyotrophic lateral sclerosis diagnosis or shortly thereafter. Death after amyotrophic lateral sclerosis diagnosis was used as the main outcome. The Cox model was used to estimate hazard ratios with 95% confidence intervals of death after amyotrophic lateral sclerosis diagnosis, after controlling for sex, age at diagnosis, site of symptom onset, diagnostic delay, body mass index, Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised score, and progression rate.

resultsA 1-SD increase of total cholesterol (hazard ratio 0.60, 95% confidence interval 0.41-0.89,

conclusionsLipids and apolipoproteins are important prognostic indicators for amyotrophic lateral sclerosis and should be monitored at the diagnosis of amyotrophic lateral sclerosis.

Indexed as

AgedAmyotrophic Lateral SclerosisApolipoproteinsBiomarkersCohort StudiesFemaleHumansLipidsMaleMiddle AgedPrognosisApolipoproteinsBiomarkersLipids

Identifiers

PMID32221024
PMCPMC7274849
OpenAlexW3013980942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.