Evidence map›Paper›PMID 32220963›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.

Xue Zhong, Lijing Su, Yi Yang, Evan Nair-Gill, Miao Tang, Priscilla Anderton, Xiaohong Li, Jianhui Wang, Xiaoming Zhan, Diana R Tomchick and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Viable mutations of mouse midnolin suppress B cell malignancies.The Journal of experimental medicine · 2024
    Article
  5. Essential role of MFSD1-GLMP-GIMAP5 in lymphocyte survival and liver homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Article
  7. Essential requirement for IER3IP1 in B cell development.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
  10. RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Xue ZhongCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Lijing SuCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Yi YangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.ORCID 0000-0003-1376-5961
Evan Nair-GillCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Miao TangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Priscilla AndertonCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Xiaohong LiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Jianhui WangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Xiaoming ZhanCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Diana R TomchickDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Chad A BrautigamDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Eva Marie Y MorescoCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Jin Huk ChoiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505; Jin.Choi@UTSouthwestern.edu Bruce.Beutler@UTSouthwestern.edu.ORCID 0000-0003-2483-4379
Bruce BeutlerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505; Jin.Choi@UTSouthwestern.edu Bruce.Beutler@UTSouthwestern.edu.ORCID 0000-0002-3639-246X
The University of Texas Southwestern Medical Center · US

Funding

Systems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NOLAN, GARRY P · 2012 to 2021
$49.1M
Automated Forward Genetic Analysis of Adaptive ImmunityR01AI125581 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI BRUCE A BEUTLER · 2016 to 2026
$19.5M
Single Crystal X-ray Diffractometer equipped with Hybrid Pixel Array Detector and In Situ Crystallization Plate Screening CapS10OD025018 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI TOMCHICK, DIANA R. · 2018 to 2018
$453k
NIAID NIH HHS R01 AI125581NIAID NIH HHS U19 AI100627NIH HHS S10 OD025018
6 · The paper itself

Abstract

The small GTPase RABL3 is an oncogene of unknown physiological function. Homozygous knockout alleles of mouse

Indexed as

LymphopoiesisAnimalsB-LymphocytesCrystallography, X-RayFemaleHerpesviridae InfectionsKiller Cells, NaturalMaleMiceMice, Inbred C57BLMice, KnockoutMuromegalovirusMutant ProteinsMutationProtein Conformationrab GTP-Binding ProteinsMutant Proteinsrab GTP-Binding ProteinsReceptors, G-Protein-CoupledGPR89lymphopoiesissmall GTPaseX-ray crystallography

Identifiers

PMID32220963
PMCPMC7165429
OpenAlexW3013507354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.