ArticleeNeuro
Differential Effects of Nasal Inflammation and Odor Deprivation on Layer-Specific Degeneration of the Mouse Olfactory Bulb.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Possible Volumetric Changes in the Hippocampus and Olfactory Bulbs After COVID-19: A Stereological MRI Study.Viruses · 2026Article
- Therapeutic Effects and Mechanisms of Olfactory Training in a Murine Model of Olfactory Dysfunction.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Olfactory Bulb Volume and Function Recovery in Eosinophilic Chronic Rhinosinusitis.The Laryngoscope · 2026Observational
- Review
- Dysbiosis of nasal microbiota associated with hippocampal neuroimmune alterations in a mouse model of eosinophilic chronic rhinosinusitis.Frontiers in immunology · 2026Article
- Neuroinflammation in Alzheimer's disease-associated sensory dysfunction: mechanistic links, actionable targets and therapeutic strategies.Frontiers in aging neuroscience · 2026Review
- Acute and chronic nasal inflammation induces lymphangiogenesis in the olfactory mucosa in mice.Brain, behavior, & immunity - health · 2025Article
- Aging and chronic inflammation: impacts on olfactory dysfunction-a comprehensive review.Cellular and molecular life sciences : CMLS · 2025Review
- Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity.Journal of virology · 2024Article
- Structures and functions of the normal and injured human olfactory epithelium.Frontiers in neural circuits · 2024Review
- Olfactory training with essential oils for patients with post-COVID-19 smell dysfunction: A case series.European journal of integrative medicine · 2023Article
- Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice.Aging cell · 2023Article
- Effects of nasal inflammation on the olfactory bulb.Journal of neuroinflammation · 2022Review
- Elevated Expression ofJournal of personalized medicine · 2022Article
- Olfactory impairment in psychiatric disorders: Does nasal inflammation impact disease psychophysiology?Translational psychiatry · 2022Review
- Deep Learning-Based Segmentation of Post-Mortem Human's Olfactory Bulb Structures in X-ray Phase-Contrast Tomography.Tomography (Ann Arbor, Mich.) · 2022Article
- Infiltration of peripheral immune cells into the olfactory bulb in a mouse model of acute nasal inflammation.Journal of neuroimmunology · 2022Article
- Microgliosis and neuronal proteinopathy in brain persist beyond viral clearance in SARS-CoV-2 hamster model.EBioMedicine · 2022Article
- Pathological consequences of chronic olfactory inflammation on neurite morphology of olfactory bulb projection neurons.Brain, behavior, & immunity - health · 2022Article
- Research Progress of Olfactory Nerve Regeneration Mechanism and Olfactory Training.Therapeutics and clinical risk management · 2022Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Harmful environmental agents cause nasal inflammation, and chronic nasal inflammation induces a loss of olfactory sensory neurons (OSNs) and reversible atrophy of the olfactory bulb (OB). Here, we investigated the mechanisms underlying this inflammation-induced OB atrophy by histologically and biochemically comparing the OB changes in mouse models of nasal inflammation and odor deprivation. In addition, we examined whether odor stimulation is necessary for OB recovery from atrophy. One group of adult male C57BL/6 mice was administered lipopolysaccharide (LPS) unilaterally for 10 weeks to induce nasal inflammation (control animals received saline), and a second group received unilateral naris closures (NCs) for 10 weeks of odor deprivation. The OBs atrophied in both models, but odor deprivation shrank the glomerular, external plexiform, mitral, and granule cell layers (GCLs), whereas the olfactory nerve, glomerular, and external plexiform layers (EPLs) atrophied as a result of nasal inflammation. Additionally, nasal inflammation, but not odor deprivation, caused neuroinflammation in the OB, inducing glial activation and elevated expression of interleukin-1β (IL-1β) and TNFα. After 10 weeks of nasal inflammation, mice were housed for another 10 weeks with no additional treatment or with unilateral NC. Nasal inflammation and glial activation subsided in both groups, but glomerular and EPLs recovered only in those with no additional treatment. Our findings demonstrate that nasal inflammation and odor deprivation differentially induce layer-specific degeneration in the OB, that loss of OSN activity rather than neuroinflammation is a major cause of inflammation-induced OB atrophy, and that odor stimulation is required for OB recovery from atrophy.
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