Evidence map›Paper›PMID 32220789›Full record

ReviewRedox biology2020

Extracellular superoxide dismutase, a molecular transducer of health benefits of exercise.

Zhen Yan, Hannah R Spaulding

Open access · goldAbstract readReview
In one paragraph

Review in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
26.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 140 citations in OpenAlex.

  1. Pooled it
  2. The effect ofFrontiers in nutrition · 2025
    Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Exploring Molecular Pathways in Exercise-Induced Recovery from Traumatic Brain Injury.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  14. Review
  15. Article
  16. Protective Mechanism ofAntioxidants (Basel, Switzerland) · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Zhen YanCenter for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA; Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA. Electronic address: zhen.yan@virginia.edu.
Hannah R SpauldingCenter for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
University of Virginia · US

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
p38 MAPK a regulator of muscle contraction and functionR01AR050429 · NIAMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI YAN, ZHEN · 2005 to 2022
$5.3M
Muscle-mediated protection against MODSR01GM114840 · NIGMS · UNIVERSITY OF VIRGINIA · PI YAN, ZHEN · 2015 to 2018
$1.2M
NHLBI NIH HHS T32 HL007284NIAMS NIH HHS R01 AR050429NIGMS NIH HHS R01 GM114840
6 · The paper itself

Abstract

Extracellular superoxide dismutase (EcSOD) is the only extracellular scavenger of superoxide anion (O

Indexed as

Superoxide DismutaseSuperoxidesAnimalsExerciseHumansOxidative StressTransducersSuperoxide DismutaseSuperoxidesEcSODEndothelial cell activationEndothelial dysfunctionExerciseOxidative stress

Identifiers

PMID32220789
PMCPMC7109453
OpenAlexW3011691351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.