Evidence map›Paper›PMID 32220056›Full record

ArticleCancer medicine2020

Time lapse analysis of tumor response in patients with soft tissue sarcoma treated with trabectedin: A pooled analysis of two phase II clinical trials.

Makoto Endo, Shunji Takahashi, Nobuhito Araki, Hideshi Sugiura, Takafumi Ueda, Tsukasa Yonemoto, Mitsuru Takahashi, Hideo Morioka, Hiroaki Hiraga, Toru Hiruma and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 12 institutions in 1 country.

Makoto EndoDepartment of Orthopaedic Surgery, Kyushu University, Fukuoka, Japan.
Shunji TakahashiDepartment of Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
Nobuhito ArakiDepartment of Orthopaedic Surgery, Osaka International Cancer Institute, Osaka, Japan.
Hideshi SugiuraDepartment of Physical Therapy, Nagoya University, Nagoya, Japan.
Takafumi UedaDepartment of Orthopaedic Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan.
Tsukasa YonemotoDivision of Orthopaedic Surgery, Chiba Cancer Center, Chiba, Japan.
Mitsuru TakahashiDivision of Orthopaedic Surgery, Shizuoka Cancer Center Hospital, Nagaizumi, Japan.
Hideo MoriokaDepartment of Orthopaedic Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Hiroaki HiragaDepartment of Orthopaedic Surgery, Hokkaido Cancer Center, Sapporo, Japan.
Toru HirumaDepartment of Musculoskeletal Tumor Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Toshiyuki KunisadaDepartment of Orthopaedic Surgery, Okayama University Hospital, Okayama, Japan.
Akihiko MatsumineDepartment of Orthopaedic Surgery, Fukui University, Fukui, Japan.
Kazato GodaDepartment of Medical affairs, Taiho Pharmaceutical Co. Ltd, Tokyo, Japan.
Akira KawaiDepartment of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo, Japan.ORCID 0000-0003-2116-586X
Chiba Cancer Center · JPJapanese Foundation For Cancer Research · JPKanagawa Prefectural Hospital Organization · JPKyushu University · JPNagoya University · JPOkayama University Hospital · JPOsaka International Cancer Institute · JPOsaka National Hospital · JPShizuoka Cancer Center · JPTaiho Pharmaceutical (Japan) · JPTokyo Medical Center · JPUniversity of Fukui · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The time course of the response to each drug is important to avoid inappropriate termination of treatment by misjudging tumor progression; however, little is known about soft tissue sarcoma (STS) regarding this matter. This study aimed to perform a time-lapse analysis of tumor response in patients with STS treated with trabectedin from 2 phase II clinical trials. We examined 66 patients with translocation-related sarcoma registered in 2 Japanese phase II clinical trials. All patients previously received standard therapy before the administration of trabectedin at 1.2 mg/m

Indexed as

AdultAgedAged, 80 and overAntineoplastic Agents, AlkylatingClinical Trials, Phase II as TopicFemaleFollow-Up StudiesHumansMaleMiddle AgedMulticenter Studies as TopicPrognosisSarcomaTime-Lapse ImagingTrabectedinYoung AdultAntineoplastic Agents, AlkylatingTrabectedinchemotherapyclinical trialsoft tissue sarcoma

Identifiers

PMID32220056
PMCPMC7286446
OpenAlexW3013604427

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.