Observational studyNeurocritical care2020
Intraventricular Hemorrhage Growth: Definition, Prevalence and Association with Hematoma Expansion and Prognosis.
Observational study in Neurocritical care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Intraventricular Hemorrhage Expansion in the CLEAR III Trial: A Post Hoc Exploratory Analysis.Stroke · 2022Trial
- Review
- Clinical, Laboratory, and CT Morphological Factors Associated with 3-Month Functional Outcomes in Spontaneous Intracerebral Hemorrhage: A Retrospective Cohort Study.Brain sciences · 2026Article
- Location-Specific Analysis of Hematoma Expansion in Intracerebral Hemorrhage.Journal of the American Heart Association · 2026Article
- A Standardized Anatomical Classification of Intracranial Hemorrhage.Cerebrovascular diseases (Basel, Switzerland) · 2026Review
- Clinical features and outcomes of intracerebral hemorrhage patients with dizziness: a multi-center cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Observational
- Noncontrast CT-based deep learning for predicting intracerebral hemorrhage expansion incorporating growth of intraventricular hemorrhage.Scientific reports · 2025Article
- Explainable CT-based deep learning model for predicting hematoma expansion including intraventricular hemorrhage growth.iScience · 2025Article
- Functional outcome after surgical treatment for spontaneous intracerebral hemorrhages: Development of the HeMAtOma score.Brain & spine · 2025Article
- Is the frequency of imaging markers still a predictor for revised intracerebral hemorrhage expansion?European stroke journal · 2024Article
- Clinical, Imaging Characteristics and Outcome of Intracerebral Hemorrhage Caused by Structural Vascular Lesions.Neurocritical care · 2024Observational
- Combining Non-Contrast CT Signs With Onset-to-Imaging Time to Predict the Evolution of Intracerebral Hemorrhage.Korean journal of radiology · 2024Article
- Morphological characteristics of CT blend sign predict hematoma expansion and outcomes in intracerebral hemorrhage in elderly patients.Frontiers in medicine · 2024Article
- Ultraearly Intraventricular Hemorrhage Growth Predicts Early Neurologic Deterioration and Poor Functional Outcome After Acute Intracerebral Hemorrhage.Journal of the American Heart Association · 2023Article
- Non-contrast computed tomography features predict intraventricular hemorrhage growth.European radiology · 2023Article
- Blood-Based Biomarkers in Intracerebral Hemorrhage.Journal of clinical medicine · 2023Review
- Machine learning-based CT radiomics model to discriminate the primary and secondary intracranial hemorrhage.Scientific reports · 2023Article
- Neutrophil percentage to albumin ratio is associated with stroke-associated pneumonia and poor outcome in patients with spontaneous intracerebral hemorrhage.Frontiers in immunology · 2023Article
- Computed tomography in acute intracerebral hemorrhage: neuroimaging predictors of hematoma expansion and outcome.Insights into imaging · 2022Review
- Aspirin does not affect hematoma growth in severe spontaneous intracranial hematoma.Neurosurgical review · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThe objective of this study is to propose a definition of intraventricular hemorrhage (IVH) growth and to investigate whether IVH growth is associated with ICH expansion and functional outcome.
methodsWe performed a prospective observational study of ICH patients between July 2011 and March 2017 in a tertiary hospital. Patients were included if they had a baseline CT scan within 6 h after onset of symptoms and a follow-up CT within 36 h. IVH growth was defined as either any newly occurring intraventricular bleeding on follow-up CT scan in patients without baseline IVH or an increase in IVH volume ≥ 1 mL on follow-up CT scan in patients with initial IVH. Poor outcome was defined as modified Rankin Scale score of 3-6 at 90 days. The association between IVH growth and functional outcome was assessed by using multivariable logistic regression analysis.
resultsIVH growth was observed in 59 (19.5%) of 303 patients. Patients with IVH growth had larger baseline hematoma volume, higher NIHSS score and lower GCS score than those without. Of 44 patients who had concurrent IVH growth and hematoma growth, 41 (93.2%) had poor functional outcome at 3-month follow-up. IVH growth (adjusted OR 4.15, 95% CI 1.31-13.20; P = 0.016) was an independent predictor of poor functional outcome (mRS 3-6) at 3 months in multivariable analysis.
conclusionIVH growth is not uncommon and independently predicts poor outcome in ICH patients. It may serve as a promising therapeutic target for intervention.
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