Evidence map›Paper›PMID 32219633›Full record

ArticleJournal of autism and developmental disorders2020

Brief Report: Reduced Heart Rate Variability in Children with Autism Spectrum Disorder.

Catharine Lory, Girija Kadlaskar, Rebecca McNally Keehn, Alexander L Francis, Brandon Keehn

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Catharine LoryDepartment of Educational Studies, Purdue University, 100 N University Street, West Lafayette, IN, 47907, USA. luo171@purdue.edu.
Girija KadlaskarDepartment of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, USA.
Rebecca McNally KeehnDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Alexander L FrancisDepartment of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, USA.
Brandon KeehnDepartment of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, USA.
Purdue University West Lafayette · USIndiana University School of Medicine

Funding

Understanding Attentional Strengths and Weaknesses in Autism Spectrum DisorderR21MH114095 · NIMH · PURDUE UNIVERSITY · PI KEEHN, BRANDON · 2018 to 2019
$415k
NIMH NIH HHS R21 MH114095NIMH NIH HHS R21-MH114095
6 · The paper itself

Abstract

Dysregulation of the autonomic nervous system (ANS), which can be indexed by heart rate variability (HRV), has been posited to contribute to core features of autism spectrum disorder (ASD). However, the relationship between ASD and HRV remains uncertain. We assessed tonic and phasic HRV of 21 children with ASD and 21 age- and IQ-matched typically developing (TD) children and examined (1) group differences in HRV and (2) associations between HRV and ASD symptomatology. Children with ASD showed significantly lower tonic HRV, but similar phasic HRV compared to TD children. Additionally, reduced tonic HRV was associated with atypical attentional responsivity in ASD. Our findings suggest ANS dysregulation is present in ASD and may contribute to atypical attentional responses to sensory stimulation.

Indexed as

Heart RateAutism Spectrum DisorderAutonomic Nervous SystemChildFemaleHumansMaleAutism spectrum disorderAutonomic arousalECGHeart rate variability

Identifiers

PMID32219633
PMCPMC7693337
OpenAlexW3013500476

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.