Evidence map›Paper›PMID 32219499›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2020

Describing the resource utilisation and costs associated withvertebral fractures: the Build Better Bones with Exercise (B3E) Pilot Trial.

S Hassan, S J Seung, R E Clark, J C Gibbs, C McArthur, N Mittmann, L Thabane, D Kendler, A Papaioannou, J D Wark and 4 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Encouraging older adults with pre-frailty and frailty to "MoveStrong": an analysis of secondary outcomes for a pilot randomized controlled trial.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2022
    Trial
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

S HassanHOPE Research Centre, Sunnybrook Research Institute, Toronto, Ontario, M4N 3M5, Canada. shazia.hassan@sunnybrook.ca.ORCID https://orcid.org/0000-0002-3040-9988
S J SeungHOPE Research Centre, Sunnybrook Research Institute, Toronto, Ontario, M4N 3M5, Canada.
R E ClarkUniversity of Waterloo, Waterloo, Canada.
J C GibbsMcGill University, Montreal, Quebec, Canada.
C McArthurMcMaster University, Hamilton, Canada.
N MittmannCancer Care Ontario, Toronto, Canada.
L ThabaneMcMaster University, Hamilton, Canada.
D KendlerUniversity of British Columbia, Vancouver, Canada.
A PapaioannouMcMaster University, Hamilton, Canada.
J D WarkUniversity of Melbourne, Melbourne, Australia.
M C AsheUniversity of British Columbia, Vancouver, Canada.
J D AdachiMcMaster University, Hamilton, Canada.
J A TempletonUniversity of Waterloo, Waterloo, Canada.
L M GiangregorioUniversity of Waterloo, Waterloo, Canada.

Funding

Canadian Institutes of Health Research (CA) 123445
6 · The paper itself

Abstract

This analysis examined costs/resources of 141 women with vertebral fractures, randomised to a home exercise programme or control group. Total, mean costs and the incremental cost-effectiveness ratio (ICER) were calculated. Quality of life was collected. Cost drivers were caregiver time, medications and adverse events (AEs). Results show adding an exercise programme may reduce the risk of AEs.

introductionThis exploratory economic analysis examined the health resource utilisation and costs experienced by women with vertebral fractures, and explored the effects of home exercise on those costs.

methodsWomen ≥ 65 years with one or more X-ray-confirmed vertebral fractures were randomised 1:1 to a 12-month home exercise programme or equal attention control group. Clinical and health system resources were collected during monthly phone calls and daily diaries completed by participants. Intervention costs were included. Unit costs were applied to health system resources. Quality of life (QoL) information was collected via EQ-5D-5L at baseline, 6 and 12 months.

resultsOne hundred and forty-one women were randomised. Overall total costs (CAD 2018) were $664,923 (intervention) and $614,033 (control), respectively. The top three cost drivers were caregiver time ($250,269 and $240,811), medications ($151,000 and $122,145) and AEs ($58,807 and $71,981). The mean cost per intervention participant of $9365 ± $9988 was higher compared with the mean cost per control participant of $8772 ± $9718. The mean EQ-5D index score was higher for the intervention participants (0.81 ± 0.11) compared with that of controls (0.79 ± 0.13). The differences in quality-adjusted life year (QALY) (0.02) and mean cost ($593) were used to calculate the ICER of $29,650.

conclusionsWomen with osteoporosis with a previous fracture experience a number of resources and associated costs that impact their care and quality of life. Caregiver time, medications and AEs are the biggest cost drivers for this population. The next steps would be to expand this feasibility study with more participants, longer-term follow-up and more regional variability.

Indexed as

Cost-Benefit AnalysisExercise TherapyHealth Care CostsAgedFemaleHumansPilot ProjectsQuality-Adjusted Life YearsQuality of LifeSpinal FracturesExerciseHealth system costsOsteoporosisResource utilisationVertebral fractures

Identifiers

PMID32219499

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.