ArticleThe American journal of clinical nutrition2020
Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother-offspring birth cohort study.
Article in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01174875 (Developmental Pathways to Health and Disease), which is not on this map. Cited by 15 papers.
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The trial behind it
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Developmental Pathways to Health and Disease: Metabolic, Neurodevelopmental and Related Outcomes
Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Altered Lipid Metabolism in Obese Women With Gestational Diabetes and Associations With Offspring Adiposity.The Journal of clinical endocrinology and metabolism · 2022Trial
- Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Association between maternal glucose levels in pregnancy and offspring's metabolism and adiposity: an 18-year birth cohort study.Diabetologia · 2025Article
- Sexual dimorphism in the association of umbilical cord blood lipidome with abdominal fat in early childhood.BMC medicine · 2025Article
- The Effect of Prenatal Docosahexaenoic Acid Supplementation on Offspring Fat Mass and Distribution at 24 Months Old.Current developments in nutrition · 2024Article
- An unwelcome inheritance: childhood obesity after diabetes in pregnancy.Diabetologia · 2023Review
- The influence of early environment and micronutrient availability on developmental epigenetic programming: lessons from the placenta.Frontiers in cell and developmental biology · 2023Review
- Associations Between Maternal Lipid Blood Levels at the 13th Week of Pregnancy and Offspring's Adiposity at Age 11-12 Years.The Journal of clinical endocrinology and metabolism · 2022Article
- Article
- Myo-inositol moderates maternal BMI and glycemia related variations in in-vitro placentalScientific reports · 2022Article
- Breastfeeding may benefit cardiometabolic health of children exposed to increased gestational glycemia in utero.European journal of nutrition · 2022Article
- The Kynurenine Pathway Metabolites in Cord Blood Positively Correlate With Early Childhood Adiposity.The Journal of clinical endocrinology and metabolism · 2022Article
- Assessment of Eating Behaviors and Perceptions of Time-Restricted Eating During Pregnancy.The Journal of nutrition · 2022Article
- The association of maternal gestational hyperglycemia with breastfeeding duration and markers of milk production.The American journal of clinical nutrition · 2021Article
- Identification of changes in sleep across pregnancy and the impact on cardiometabolic health and energy intake in women with obesity.Sleep medicine · 2021Observational
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17 authors at 5 institutions in 5 countries.
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Abstract
backgroundGestational diabetes is associated with unfavorable body fat distribution in offspring. However, less is known about the effects across the range of maternal gestational glycemia on offspring abdominal adiposity (AA) in infancy and early childhood.
objectivesThis study determined the association between gestational glycemia and offspring AA measured by MRI in the neonatal period and during the preschool years.
methodsParticipants were mother-offspring pairs from the GUSTO (Growing Up in Singapore Towards healthy Outcomes) prospective cohort study. Children who underwent MRI within 2 wk postdelivery (n = 305) and/or at preschool age, 4.5 y (n = 273), and whose mothers had a 2-h 75-g oral-glucose-tolerance test (OGTT) at 26-28 weeks of gestation were included. AA measured by adipose tissue compartment volumes-abdominal superficial (sSAT), deep subcutaneous (dSAT), and internal (IAT) adipose tissue-was quantified from MRI images.
resultsAdjusting for potential confounders including maternal prepregnancy BMI, each 1-mmol/L increase in maternal fasting glucose was associated with higher SD scores for sSAT (0.66; 95% CI: 0.45, 0.86), dSAT (0.65; 95% CI: 0.44, 0.87), and IAT (0.64; 95% CI: 0.42, 0.86) in neonates. Similarly, each 1-mmol/L increase in 2-h OGTT glucose was associated with higher neonatal sSAT (0.11; 95% CI: 0.03, 0.19) and dSAT (0.09; 95% CI: 0.00, 0.17). These associations were stronger in female neonates but only persisted in girls between fasting glucose, and sSAT and dSAT at 4.5 y.
conclusionsA positive association between maternal glycemia and neonatal AA was observed across the whole range of maternal mid-gestation glucose concentrations. These findings may lend further support to efforts toward optimizing maternal hyperglycemia during pregnancy. The study also provides suggestive evidence on sex differences in the impact of maternal glycemia, which merits further confirmation in other studies.This trial was registered at clinicaltrials.gov as NCT01174875.
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