Evidence map›Paper›PMID 32219418›Full record

ArticleThe American journal of clinical nutrition2020

Eating behaviors moderate the associations between risk factors in the first 1000 days and adiposity outcomes at 6 years of age.

Anna Fogel, Keri McCrickerd, Izzuddin M Aris, Ai Ting Goh, Yap-Seng Chong, Kok Hian Tan, Fabian Yap, Lynette P Shek, Michael J Meaney, Birit F P Broekman and 7 more

Registry-linked trialAbstract read
In one paragraph

Article in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01174875 (Developmental Pathways to Health and Disease), which is not on this map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01174875 active not recruitingnot on this map

Developmental Pathways to Health and Disease: Metabolic, Neurodevelopmental and Related Outcomes

TypeobservationalSponsorNational University Hospital, SingaporeRan2009 to 2029Enrolled1,247ConditionsMetabolic Diseases, Neurological and Mental Health Conditions, Genetic Predisposition, Skin Condition
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Anna FogelClinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), National University Health System, Singapore.
Keri McCrickerdClinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), National University Health System, Singapore.
Izzuddin M ArisDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Ai Ting GohClinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), National University Health System, Singapore.
Yap-Seng ChongSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
Kok Hian TanDepartment of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore.
Fabian YapDepartment of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore.
Lynette P ShekSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
Michael J MeaneySingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
Birit F P BroekmanSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
Keith M GodfreyMedical Research Council Lifecourse Epidemiology Unit and National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
Mary F F ChongClinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), National University Health System, Singapore.
Shirong CaiSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
Wei Wei PangDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Wen Lun YuanDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Yung Seng LeeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
Ciarán G FordeClinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), National University Health System, Singapore.

Funding

British Heart Foundation RG/15/17/31749Medical Research Council MC_UU_12011/4
6 · The paper itself

Abstract

backgroundSeveral risk factors in the first 1000 d are linked with increased obesity risk in later childhood. The role of potentially modifiable eating behaviors in this association is unclear.

objectivesThis study examined whether the association between cumulated risk factors in the first 1000 d and adiposity at 6 y is moderated by eating behaviors.

methodsParticipants were 302 children from the GUSTO (Growing Up in Singapore Towards healthy Outcomes) cohort. Risk factors included maternal prepregnancy and paternal overweight, excessive gestational weight gain, raised fasting plasma glucose during pregnancy, short breastfeeding duration, and early introduction of solid foods. Composite risk scores reflecting the prevalence and the importance of the risk factors present were computed. Adiposity outcomes were child BMI and sum of skinfolds (SSF), and candidate eating behavior moderators were portion size, eating rate, and energy intake during lunch and in an eating in the absence of hunger task.

resultsHigher composite risk score predicted higher BMI z scores (B = 0.08; 95% CI: 0.04, 0.13) and larger SSF (0.70 mm; 0.23, 1.18 mm), and was associated with larger self-served food portions (5.03 kcal; 0.47, 9.60 kcal), faster eating rates (0.40 g/min; 0.21, 0.59 g/min), and larger lunch intakes (7.05 kcal; 3.37, 10.74 kcal). Importantly, the association between composite risk score and adiposity was moderated by eating behaviors. The composite risk score was unrelated to SSF in children who selected smaller food portions, ate slower, and consumed less energy, but was positively associated with SSF among children who selected larger food portions, ate faster, and consumed more energy (eating behavior × risk score interactions: P < 0.05).

conclusionsThe association between risk factors in the first 1000 d and adiposity at 6 y varies by eating behaviors, highlighting modifiable behavioral targets for interventions.This trial was registered at clinicaltrials.gov as NCT01174875.

Indexed as

AdiposityFeeding BehaviorBody Mass IndexBreast FeedingChild, PreschoolCohort StudiesEnergy IntakeFemaleHumansHungerInfantMaleOverweightPregnancyRisk FactorsSingapore1000 daysadiposityadiposity outcomeschildhood obesityeating behavioreating in the absence of hungereating rateenergy intakeportion sizerisk factors

Identifiers

PMID32219418
PMCPMC7332343

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.