ArticleCerebral cortex (New York, N.Y. : 1991)2020
Temporal Patterns of Emergence and Spatial Distribution of Sulcal Pits During Fetal Life.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 30 citations in OpenAlex.
- Linking maternal blood pressure with fetal cerebral haemodynamics and cortical growth in congenital heart disease.EBioMedicine · 2026Article
- Typical development of the human fetal subplate: Regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- How do infant brains fold? Sulcal deepening is linked to development of sulcal span, thickness, curvature, and microstructure.Communications biology · 2026Article
- Long-term effects of preterm birth on cortical folding trajectories in early childhood.Brain communications · 2026Article
- Mechanics of the Spatiotemporal Evolution of Sulcal Pits in the Folding Brain.Human brain mapping · 2025Article
- Sulcal pits as potential markers of early sex-related human brain differences in healthy adults.Biology of sex differences · 2025Article
- Foetal cortical expansion is associated with neurodevelopmental outcome at 2-years in congenital heart disease: a longitudinal follow-up study.EBioMedicine · 2025Article
- Flight training and alterations in cortical characteristics.Frontiers in human neuroscience · 2025Article
- Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo.bioRxiv : the preprint server for biology · 2024Article
- Characterizing Large-Scale Human Circuit Development with In Vivo Neuroimaging.Cold Spring Harbor perspectives in biology · 2024Review
- Association between placental oxygen transport and fetal brain cortical development: a study in monochorionic diamniotic twins.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Automatic cortical surface parcellation in the fetal brain using attention-gated spherical U-net.Frontiers in neuroscience · 2024Article
- Sulcal pits of the superior temporal sulcus in schizophrenia patients with auditory verbal hallucinations.AIMS neuroscience · 2024Article
- Quantification of sulcal emergence timing and its variability in early fetal life: Hemispheric asymmetry and sex difference.NeuroImage · 2022Article
- Abnormal Right-Hemispheric Sulcal Patterns Correlate with Executive Function in Adolescents with Tetralogy of Fallot.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Abnormal Left-Hemispheric Sulcal Patterns in Adults With Simple Congenital Heart Defects Repaired in Childhood.Journal of the American Heart Association · 2021Article
- Regional Alterations in Cortical Sulcal Depth in Living Fetuses with Down Syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Towards Deciphering the Fetal Foundation of Normal Cognition and Cognitive Symptoms From Sulcation of the Cortex.Frontiers in neuroanatomy · 2021Article
- Optimal Method for Fetal Brain Age Prediction Using Multiplanar Slices From Structural Magnetic Resonance Imaging.Frontiers in neuroscience · 2021Article
- Fetal Cortical Plate Segmentation Using Fully Convolutional Networks With Multiple Plane Aggregation.Frontiers in neuroscience · 2020Article
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Authors and funding
7 authors at 3 institutions in 1 country.
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Abstract
Sulcal pits are thought to represent the first cortical folds of primary sulci during neurodevelopment. The uniform spatial distribution of sulcal pits across individuals is hypothesized to be predetermined by a human-specific protomap which is related to functional localization under genetic controls in early fetal life. Thus, it is important to characterize temporal and spatial patterns of sulcal pits in the fetal brain that would provide additional information of functional development of the human brain and crucial insights into abnormal cortical maturation. In this paper, we investigated temporal patterns of emergence and spatial distribution of sulcal pits using 48 typically developing fetal brains in the second half of gestation. We found that the position and spatial variance of sulcal pits in the fetal brain are similar to those in the adult brain, and they are also temporally uniform against dynamic brain growth during fetal life. Furthermore, timing of pit emergence shows a regionally diverse pattern that may be associated with the subdivisions of the protomap. Our findings suggest that sulcal pits in the fetal brain are useful anatomical landmarks containing detailed information of functional localization in early cortical development and maintaining their spatial distribution throughout the human lifetime.
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