ArticleCerebral cortex (New York, N.Y. : 1991)2020
Multiple Brain Networks Mediating Stimulus-Pain Relationships in Humans.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed.
- Multimodal approach to identify neuropsychophysiological subgroups in myalgic encephalomyelitis/chronic fatigue syndrome and their relevance for rehabilitation: protocol for a mechanistic cross-sectional and longitudinal study.Brain, behavior, & immunity - health · 2026Article
- Lower resting-state functional connectivity between frontoparietal and sensory networks is associated with recent pain intensity in a community sample of youth.Neuroimage. Reports · 2026Article
- The functional neurobiology of dispositions towards negative emotions.Nature communications · 2026Article
- Gestational PBDE concentrations and functional connectivity in adolescents: The HOME Study.International journal of hygiene and environmental health · 2026Article
- A GABAergic pathway from dorsal raphe nucleus to paraventricular thalamic nucleus modulates incision-related pain behaviour in mice.Brain communications · 2026Article
- Nonsuicidal self-injury prediction with pain-processing neural circuits using interpretable graph neural network.Annals of medicine · 2025Article
- The posterior capsular central amygdala showing synaptic coactivation with nociplastic pain-associated parabrachial neurons in mice.iScience · 2025Article
- The Anatomical and Evolutionary Impact of Pain, Pleasure, Motivation, and Cognition: Integrating Energy Metabolism and the Mind-Body BERN (Behavior, Exercise, Relaxation, and Nutrition) Framework.International journal of molecular sciences · 2025Review
- The functional neurobiology of negative affective traits across regions, networks, signatures, and a machine learning multiverse.bioRxiv : the preprint server for biology · 2025Article
- Temporoparietal brain structures support sentence processing across the adult lifespan.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Information search under uncertainty across transdiagnostic psychopathology and healthy ageing.Translational psychiatry · 2024Article
- Network-Assisted Mediation Analysis with High-Dimensional Neuroimaging Mediators.Proceedings of machine learning research · 2024Article
- Article
- Towards a Real-Life Understanding of the Altered Functional Behaviour of the Default Mode and Salience Network in Chronic Pain: Are People with Chronic Pain Overthinking the Meaning of Their Pain?Journal of clinical medicine · 2024Review
- Medial Prefrontal Cortex Dysfunction Mediates Working Memory Deficits in Patients With Schizophrenia.Biological psychiatry global open science · 2023Article
- Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes.Translational psychiatry · 2023Article
- The DNA methylation landscape of the human oxytocin receptor gene (OXTR): data-driven clusters and their relation to gene expression and childhood adversity.Translational psychiatry · 2023Article
- Article
- Associations between neighborhood socioeconomic status, parental education, and executive system activation in youth.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The Role of the Skin in Interoception: A Neglected Organ?Perspectives on psychological science : a journal of the Association for Psychological Science · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The brain transforms nociceptive input into a complex pain experience comprised of sensory, affective, motivational, and cognitive components. However, it is still unclear how pain arises from nociceptive input and which brain networks coordinate to generate pain experiences. We introduce a new high-dimensional mediation analysis technique to estimate distributed, network-level patterns that formally mediate the relationship between stimulus intensity and pain. We applied the model to a large-scale analysis of functional magnetic resonance imaging data (N = 284), focusing on brain mediators of the relationship between noxious stimulus intensity and trial-to-trial variation in pain reports. We identify mediators in both traditional nociceptive pathways and in prefrontal, midbrain, striatal, and default-mode regions unrelated to nociception in standard analyses. The whole-brain mediators are specific for pain versus aversive sounds and are organized into five functional networks. Brain mediators predicted pain ratings better than previous brain measures, including the neurologic pain signature (Wager et al. 2013). Our results provide a broader view of the networks underlying pain experience, as well as novel brain targets for interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.