ArticleScience advances2020
3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
125 citing papers in PubMed, 370 citations in OpenAlex.
- Efficacy and safety of autologous or allogeneic mesenchymal stromal cells from adult adipose tissue expanded and combined with tricalcium phosphate biomaterial for the surgical treatment of atrophic nonunion of long bones: a phase II clinical trial.Journal of translational medicine · 2024Trial
- The application of growth factors in bone tissue engineering delivery systems and collaborative innovation strategies.Annals of medicine · 2026Review
- Research hotspots and emerging trends of 3D printing in bone defects: a bibliometric analysis based on Web of Science core collection from 2006 to March 2026.Cell and tissue banking · 2026Article
- Tissue Engineering for Massive Bone Defects: The Volumetric Scaling Problem and Strategies to Solve It.Bioengineering (Basel, Switzerland) · 2026Review
- Biomaterial-assisted gene therapy for bone repair.Materials today. Bio · 2026Review
- Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Data-driven multiscale design of composite biomaterials: Integrating experiments, imaging, and computational modeling for biomedical engineering.Materials today. Bio · 2026Review
- Design and Fabrication of Biomimetic Gradient Bone Tissue Engineering Scaffolds: Evolution from Single-Gradient to Multi-Gradient.Gels (Basel, Switzerland) · 2026Review
- Biomaterial-assisted neuralization strategies for tissue engineering applications.Materials today. Bio · 2026Review
- Elevator-Like Hollow Channels in Porous Scaffolds Accelerate Vascularized Bone Regeneration via NETs-Fibrin-Mediated Macrophage Recruitment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- 3D-bioprinting for joint regeneration.Frontiers in bioengineering and biotechnology · 2026Review
- Advancing the 3Rs in bone tissue engineering: emergingFrontiers in physiology · 2026Review
- Biomimetic Nanoparticles for Bone Regeneration: Construction Strategies and Therapeutic Mechanisms.International journal of nanomedicine · 2026Review
- Building the next frontier: Artificial intelligence in 3D-printed medicines.Biomaterials translational · 2026Review
- The Sr-HA-loaded PLGA cage structure combines cells to construct a bone tissue repair unit.Regenerative biomaterials · 2026Article
- Functionalization of 3D printed PLGA-based scaffolds for bone regeneration.Regenerative therapy · 2025Review
- A Tissue Engineering's Guide to Biomimicry.Macromolecular bioscience · 2025Review
- Integrating Additive and Traditional Manufacturing for Multiscale Bone Tissue Engineering Scaffolds.Journal of functional biomaterials · 2025Review
- Bioinspired 3D Bone Model: Mimicking the Cortical-Spongy Bone Architecture and Biology for Enhanced Physiological Representation of Bone.ACS biomaterials science & engineering · 2025Article
- Lumbrokinase-loaded GelMA hydrogels with inflammatory regulatory capacity promote vascularized bone regeneration in critical-sized cranial defects.RSC advances · 2025Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, the complexity of hierarchical structures, the requirement for mechanical properties, and the diversity of bone resident cells are the major challenges in constructing biomimetic bone tissue engineering scaffolds. Herein, a Haversian bone-mimicking scaffold with integrated hierarchical Haversian bone structure was successfully prepared via digital laser processing (DLP)-based 3D printing. The compressive strength and porosity of scaffolds could be well controlled by altering the parameters of the Haversian bone-mimicking structure. The Haversian bone-mimicking scaffolds showed great potential for multicellular delivery by inducing osteogenic, angiogenic, and neurogenic differentiation in vitro and accelerated the ingrowth of blood vessels and new bone formation in vivo. The work offers a new strategy for designing structured and functionalized biomaterials through mimicking native complex bone tissue for tissue regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.