Evidence map›Paper›PMID 32219158›Full record

ArticleScience advances2020

Massively parallel microwire arrays integrated with CMOS chips for neural recording.

Abdulmalik Obaid, Mina-Elraheb Hanna, Yu-Wei Wu, Mihaly Kollo, Romeo Racz, Matthew R Angle, Jan Müller, Nora Brackbill, William Wray, Felix Franke and 5 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 185 citations in OpenAlex.

  1. Article
  2. Review
  3. Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  6. Ultrasensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  15. Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  16. Article
  17. Flexible 3D Kirigami Probes for In Vitro and In Vivo Neural Applications.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  18. Article
  19. Direct-Print 3D Electrodes for Large-Scale, High-Density, and Customizable Neural Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  20. Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Abdulmalik ObaidDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1670-4419
Mina-Elraheb HannaDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Yu-Wei WuDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-4459-087X
Mihaly KolloNeurophysiology of Behaviour Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0002-0147-6997
Romeo RaczNeurophysiology of Behaviour Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0003-1438-6226
Matthew R AngleParadromics Inc., Austin, TX, USA.ORCID 0000-0002-2601-7631
Jan MüllerDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Nora BrackbillDepartment of Physics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0308-1382
William WrayNeurophysiology of Behaviour Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0002-5126-372X
Felix FrankeDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.ORCID 0000-0001-5550-1222
E J ChichilniskyDepartments of Neurosurgery and Ophthalmology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-5613-0248
Andreas HierlemannDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Jun B DingDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0690-1312
Andreas T SchaeferNeurophysiology of Behaviour Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0002-4677-8788
Nicholas A MeloshDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2601-1379
Stanford University · USThe Francis Crick Institute · GBETH Zurich · CHStanford Medicine · US

Funding

Massive scale electrical neural recordings in vivo using commercial ROIC chipsU01NS094248 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KORDING, KONRAD P., SCHAEFER, ANDREAS · 2015 to 2017
$1.9M
Commercial development of microwire bundle technology for massively parallel neural recording.R43MH110287 · NIMH · PARADROMICS, INC. · PI ANGLE, MATTHEW R, MELOSH, NICHOLAS A · 2016 to 2017
$798k
Massively parallel microwire arrays for deep brain stimulationR21NS104861 · NINDS · STANFORD UNIVERSITY · PI DING, JUN · 2018 to 2019
$434k
Medical Research Council MC_UP_1202/5NIMH NIH HHS R43 MH110287NINDS NIH HHS R21 NS104861NINDS NIH HHS U01 NS094248Wellcome Trust FC001153
6 · The paper itself

Abstract

Multi-channel electrical recordings of neural activity in the brain is an increasingly powerful method revealing new aspects of neural communication, computation, and prosthetics. However, while planar silicon-based CMOS devices in conventional electronics scale rapidly, neural interface devices have not kept pace. Here, we present a new strategy to interface silicon-based chips with three-dimensional microwire arrays, providing the link between rapidly-developing electronics and high density neural interfaces. The system consists of a bundle of microwires mated to large-scale microelectrode arrays, such as camera chips. This system has excellent recording performance, demonstrated via single unit and local-field potential recordings in isolated retina and in the motor cortex or striatum of awake moving mice. The modular design enables a variety of microwire types and sizes to be integrated with different types of pixel arrays, connecting the rapid progress of commercial multiplexing, digitisation and data acquisition hardware together with a three-dimensional neural interface.

Indexed as

ElectronicsMicrochip Analytical ProceduresAnimalsEquipment DesignLab-On-A-Chip DevicesMiceMicroelectrodesNeurons

Identifiers

PMID32219158
PMCPMC7083623
OpenAlexW3011035326

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.