Evidence map›Paper›PMID 32219148›Full record

ArticleBioMed research international2020

Antiapolipoprotein A-1 Autoantibody Positivity Is Associated with Threatened Abortion.

Alessandra Vecchié, Aldo Bonaventura, Federico Carbone, Davide Maggi, Antonella Ferraiolo, Beatrice Carloni, Gabriella Andraghetti, Laura Affinito Bonabello, Luca Liberale, Vanessa Fetaud and 5 more

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Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Alessandra VecchiéFirst Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 Viale Benedetto XV, 16132 Genoa, Italy.
Aldo BonaventuraFirst Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 Viale Benedetto XV, 16132 Genoa, Italy.ORCID https://orcid.org/0000-0002-4747-5535
Federico CarboneFirst Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 Viale Benedetto XV, 16132 Genoa, Italy.ORCID https://orcid.org/0000-0003-2957-4078
Davide MaggiDiabetology Unit, Department of Internal Medicine, University of Genoa, 6 Viale Benedetto XV, 16132 Genoa, Italy.
Antonella FerraioloDepartment of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino Genova, 10 Largo Benzi, 16132 Genoa, Italy.
Beatrice CarloniDiabetology Unit, Department of Internal Medicine, University of Genoa, 6 Viale Benedetto XV, 16132 Genoa, Italy.
Gabriella AndraghettiDepartment of Internal Medicine, University of Genoa, 6 Viale Benedetto XV, 16132 Genoa, Italy.
Laura Affinito BonabelloDiabetology Unit, Department of Internal Medicine, University of Genoa, 6 Viale Benedetto XV, 16132 Genoa, Italy.
Luca LiberaleFirst Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 Viale Benedetto XV, 16132 Genoa, Italy.ORCID https://orcid.org/0000-0003-1472-7975
Vanessa FetaudDivision of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, 4 Rue Gabrielle-Perret-Gentil, 1205 Geneva, Switzerland.
Sabrina PaganoDivision of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, 4 Rue Gabrielle-Perret-Gentil, 1205 Geneva, Switzerland.
Franco DallegriFirst Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 Viale Benedetto XV, 16132 Genoa, Italy.
Renzo CorderaDiabetology Unit, Department of Internal Medicine, University of Genoa, 6 Viale Benedetto XV, 16132 Genoa, Italy.
Fabrizio MontecuccoIRCCS Ospedale Policlinico San Martino Genova-Italian Cardiovascular Network, 10 Largo Benzi, 16132 Genoa, Italy.ORCID https://orcid.org/0000-0003-0823-8729
Nicolas VuilleumierDivision of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, 4 Rue Gabrielle-Perret-Gentil, 1205 Geneva, Switzerland.
University of Genoa · ITOspedale Policlinico San Martino · ITUniversity Hospital of Geneva · CHVirginia Commonwealth University · USUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutoantibodies against apolipoprotein A-1 (anti-ApoA-1 IgG) were demonstrated to be associated with cardiovascular outcomes in several inflammatory diseases. As balanced inflammation is critical for uncomplicated pregnancy, we aimed to investigate the prevalence of anti-ApoA-1 IgG and anti-c-terminal ApoA-1 autoantibodies (Ac-terAA1 IgG) in a cohort of pregnant women and their potential relationship with threatened abortion (TA).

methodsBetween 2012 and 2014, 371 consecutive outpatient pregnant women were included in this study and followed until delivery. Anti-ApoA-1 and anti-Ac-terAA1 IgG were measured by ELISA technique on serum samples collected between the 24

resultsMedian age was 34 with a prevalence of the Caucasian ethnicity (90.5%). TA occurred in 10 women (2.7%). C-statistics indicated that anti-ApoA-1 and anti-Ac-terAA1 IgG levels upon study inclusion were predictive of TA (0.73, 95% confidence interval [CI] 0.69-0.78,

conclusionAnti-ApoA-1 and anti-Ac-terAA1 IgG are independently associated with TA during pregnancy with an appealing NPV. The causal biological mechanisms underlying this association as well as the possible clinical relevance of these findings require further investigations.

Indexed as

Abortion, ThreatenedAdultApolipoprotein A-IAutoantibodiesBiomarkersC-Reactive ProteinFemaleHumansImmunoglobulin GInflammationPregnancyPrevalenceRisk FactorsApolipoprotein A-IAutoantibodiesBiomarkersC-Reactive ProteinImmunoglobulin G

Identifiers

PMID32219148
PMCPMC7081016
OpenAlexW3009351712

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.