Evidence map›Paper›PMID 32218999›Full record

ArticleNPJ vaccines2020

Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India.

Sudhir Babji, Punithavathy Manickavasagam, Yin-Huai Chen, Nithya Jeyavelu, Nisha Vincy Jose, Ira Praharaj, Chanduni Syed, Saravanakumar Puthupalayam Kaliappan, Jacob John, Sidhartha Giri and 7 more

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Sudhir Babji1Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004 India.ORCID 0000-0002-1288-374X
Punithavathy Manickavasagam1Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004 India.
Yin-Huai Chen2Translational Gastroenterology Unit, Nuffield Department of Medicine, and Department of Paediatrics, University of Oxford, Oxford, OX3 9DU UK.
Nithya Jeyavelu1Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004 India.
Nisha Vincy Jose1Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004 India.ORCID 0000-0003-1110-7746
Ira Praharaj1Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004 India.ORCID 0000-0002-0541-1146
Chanduni Syed1Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004 India.
Saravanakumar Puthupalayam Kaliappan3Department of Community Health, Christian Medical College, Vellore, Tamil Nadu 632004 India.ORCID 0000-0002-1904-6880
Jacob John3Department of Community Health, Christian Medical College, Vellore, Tamil Nadu 632004 India.
Sidhartha Giri1Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004 India.ORCID 0000-0003-3927-7392
Srinivasan Venugopal1Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004 India.
Beate Kampmann4The Vaccine Centre, London School of Hygiene and Tropical Medicine, London, WC1E 7HT UK.
Edward P K Parker4The Vaccine Centre, London School of Hygiene and Tropical Medicine, London, WC1E 7HT UK.
Miren Iturriza-Gómara5Institute of Infection and Global Health, University of Liverpool, Liverpool, L69 7BE UK.
Gagandeep Kang1Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004 India.
Nicholas C Grassly *6Department of Infectious Disease Epidemiology, Imperial College London, London, W2 1PG UK.ORCID 0000-0001-6067-4507
Holm H Uhlig *2Translational Gastroenterology Unit, Nuffield Department of Medicine, and Department of Paediatrics, University of Oxford, Oxford, OX3 9DU UK.
Christian Medical College, Vellore · INUniversity of London · GBUniversity of Oxford · GBImperial College London · GBUniversity of Liverpool · GB

Funding

Multi-disciplinary research training in enteric infectionsD43TW007392 · FIC · CHRISTIAN MEDICAL COLLEGE · PI KANG, GAGANDEEP · 2005 to 2020
$2.9M
Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) OPP1039135FIC NIH HHS D43 TW007392Medical Research Council MR/R015600/1Wellcome Trust
6 · The paper itself

Abstract

Identification of the causes of poor oral vaccine immunogenicity in low-income countries might lead to more effective vaccines. We measured mucosal and systemic immune parameters at the time of vaccination with oral poliovirus vaccine (OPV) in 292 Indian infants aged 6-11 months, including plasma cytokines, leukocyte counts, fecal biomarkers of environmental enteropathy and peripheral blood T-cell phenotype, focused on gut-homing regulatory CD4+ populations. We did not find a distinct immune phenotype associated with OPV immunogenicity, although viral pathogens were more prevalent in stool at the time of immunization among infants who failed to seroconvert (63.9% vs. 45.6%,

Indexed as

Live attenuated vaccinesPaediatric research

Identifiers

PMID32218999
PMCPMC7089977
OpenAlexW3012605117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.