ArticleRoyal Society open science2020
A unified rheological model for cells and cellularised materials.
Article in Royal Society open science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 66 citations in OpenAlex.
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- Plectin affects cell viscoelasticity at small and large deformations.Biophysical journal · 2026Article
- Rupture strength of living cell monolayers.Nature materials · 2024Article
- Biomechanical Modelling of Porcine Kidney.Bioengineering (Basel, Switzerland) · 2024Article
- Review
- Rheology of marine sponges reveals anisotropic mechanics and tuned dynamics.Journal of the Royal Society, Interface · 2022Article
- Linear viscoelastic properties of the vertex model for epithelial tissues.PLoS computational biology · 2022Article
- Dynamic alteration of poroelastic attributes as determinant membrane nanorheology for endocytosis of organ specific targeted gold nanoparticles.Journal of nanobiotechnology · 2022Article
- Cell nucleus as a microrheological probe to study the rheology of the cytoskeleton.Biophysical journal · 2021Article
- 3D Cell Culture for the Study of Microenvironment-Mediated Mechanostimuli to the Cell Nucleus: An Important Step for Cancer Research.Frontiers in molecular biosciences · 2021Article
- Viscoelasticity in simple indentation-cycle experiments: a computational study.Scientific reports · 2020Article
- Adaptive viscoelasticity of epithelial cell junctions: from models to methods.Current opinion in genetics & development · 2020Review
- Cell spheroid fusion: beyond liquid drops model.Scientific reports · 2020Article
- Double power-law viscoelastic relaxation of living cells encodes motility trends.Scientific reports · 2020Article
- A unified rheological model for cells and cellularised materials.Royal Society open science · 2020Article
- Mechanosensitive Junction Remodeling Promotes Robust Epithelial Morphogenesis.Biophysical journal · 2019Article
- Viscoelasticity during development: What is it? and why should you care?Seminars in cell & developmental biologyReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanical response of single cells and tissues exhibits a broad distribution of time-scales that often gives rise to a distinctive power-law rheology. Such complex behaviour cannot be easily captured by traditional rheological approaches, making material characterisation and predictive modelling very challenging. Here, we present a novel model combining conventional viscoelastic elements with fractional calculus that successfully captures the macroscopic relaxation response of epithelial monolayers. The parameters extracted from the fitting of the relaxation modulus allow prediction of the response of the same material to slow stretch and creep, indicating that the model captured intrinsic material properties. Two characteristic times, derived from the model parameters, delimit different regimes in the materials response. We compared the response of tissues with the behaviour of single cells as well as intra and extra-cellular components, and linked the power-law behaviour of the epithelium to the dynamics of the cell cortex. Such a unified model for the mechanical response of biological materials provides a novel and robust mathematical approach to consistently analyse experimental data and uncover similarities and differences in reported behaviour across experimental methods and research groups. It also sets the foundations for more accurate computational models of tissue mechanics.
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Registered trials
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