Evidence map›Paper›PMID 32218704›Full record

ArticleInternational journal of medical sciences2020

Assessment of Anti-Tumor potential and safety of application of Glutathione stabilized Gold Nanoparticles conjugated with Chemotherapeutics.

Karol P Steckiewicz, Ewelina Barcinska, Katarzyna Sobczak, Ewelina Tomczyk, Michał Wojcik, Iwona Inkielewicz-Stepniak

Abstract read
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In one paragraph

Article in International journal of medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karol P SteckiewiczChair and Department of Medical Chemistry, Medical University of Gdansk, Debinki street 1, 80-211 Gdansk, Poland.
Ewelina BarcinskaChair and Department of Medical Chemistry, Medical University of Gdansk, Debinki street 1, 80-211 Gdansk, Poland.
Katarzyna SobczakFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Ewelina TomczykFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Michał WojcikFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Iwona Inkielewicz-StepniakChair and Department of Medical Chemistry, Medical University of Gdansk, Debinki street 1, 80-211 Gdansk, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the high toxicity of currently used chemotherapeutics, novel methods of cancer treatment are needed. Gold nanoparticles (AuNPs) seem to be an interesting alternative due to penetration through biological membranes and systemic barriers. AuNPs as carriers of chemotherapeutics allow for reduced concentrations whilst maintaining the expected effect, and thus reducing the costs of therapy and adverse effects. We synthesized AuNPs stabilized with reduced glutathione (GSH) and conjugated with doxorubicin (DOX), gemcitabine (GEM) or cytarabine (CTA). This is the first study in which cytarabine-AuNPs were synthesized and characterized. Transmission electron microscopy (TEM), thermogravimetric analysis (TGA), nuclear magnetic resonance spectroscopy (NMR) and high-performance liquid chromatography (HPLC) were used to chemically characterize obtained nanoparticles. Antitumor activity and safety of application were assessed by MTT assay in

Indexed as

Chromatography, High Pressure LiquidCytarabineDeoxycytidineDoxorubicinGemcitabineGlutathioneGoldHumansMCF-7 CellsMetal NanoparticlesMicroscopy, Electron, TransmissionNeoplasmsOsteoblastsTelomeraseCytarabineDeoxycytidineDoxorubicinGemcitabineGlutathioneGoldTelomeraseTERT protein, humanCancerChemotherapeuticDrug deliver platformGold nanoparticlesGold nanoparticles conjugate

Identifiers

PMID32218704
PMCPMC7085271

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.