ArticlePloS one2020
Potential gains in life expectancy from reducing amenable mortality among people diagnosed with serious mental illness in the United Kingdom.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Global Prevalence of Metabolic Syndrome in Schizophrenia Patients: A Systematic Review and Meta-Analysis.Journal of prevention (2022) · 2024Pooled it
- Diagnostic overshadowing: An evolutionary concept analysis on the misattribution of physical symptoms to pre-existing psychological illnesses.International journal of mental health nursing · 2022Pooled it
- Psychotropic Drugs and Adverse Kidney Effects: A Systematic Review of the Past Decade of Research.CNS drugs · 2022Pooled it
- Integrated physical and mental healthcare for older adults in Europe: from concept to implementation-a joint EuGMS and EAGP perspectives paper.European geriatric medicine · 2026Article
- Characteristics of people with severe mental illness excluded from incentivised physical health checks in the UK: electronic healthcare record study.The British journal of psychiatry : the journal of mental science · 2026Article
- Pulse wave velocity is elevated in people with serious mental illness with vascular age advanced in two-thirds of individuals.Cardiovascular endocrinology & metabolism · 2026Article
- Electrocardiographic Abnormalities in Elderly Patients Receiving Psychotropic Therapy in the Emergency Department: A Retrospective Cohort Study.Life (Basel, Switzerland) · 2025Article
- Brief interventions for smoking or alcohol moderated by history of mental health condition: a national survey of adults in Great Britain 2020-2023.BMJ mental health · 2025Article
- Factors Associated with Weight Change in Adults with Severe Mental Illness: Results from a Large Cross-Sectional Survey.Nutrients · 2025Article
- The Impact of Structural Integration on Clinical Outcomes among Individuals with Serious Mental Illness and Chronic Illness.Community mental health journal · 2024Article
- Telomere biology and its maintenance in schizophrenia spectrum disorders: Exploring links to cognition.Schizophrenia research · 2024Article
- Speak for yourself: usability and acceptability of audio diaries to explore physical activity, sedentary and sleep behaviours of those living with severe mental illness.Journal of activity, sedentary and sleep behaviors · 2024Article
- Responsible coordination of municipal health and care services for individuals with serious mental illness: a participatory qualitative study with service users and professionals.BMC health services research · 2024Article
- Overcoming Stigma: The Human Side of Monkeypox Virus.Advances in experimental medicine and biology · 2024Review
- Severe mental illness, race/ethnicity, multimorbidity and mortality following COVID-19 infection: nationally representative cohort study.The British journal of psychiatry : the journal of mental science · 2023Article
- Receptor-Independent Therapies for Forensic Detainees with Schizophrenia-Dementia Comorbidity.International journal of molecular sciences · 2023Article
- Transdiagnostic evaluation of epigenetic age acceleration and burden of psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Outcomes Among People With Schizophrenia Participating in General-Population Smoking Cessation Treatment: An Observational Study.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Observational
- Health-risk behaviours among people with severe mental ill health: understanding modifiable risk in the Closing the Gap Health Study.The British journal of psychiatry : the journal of mental science · 2023Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundTo estimate the potential gain in life expectancy from addressing modifiable risk factors for all-cause mortality (excluding suicide and deaths from accidents or violence) across specific serious mental illness (SMI) subgroups, namely schizophrenia, schizoaffective disorders, and bipolar disorders in a Western population.
methodsWe have used relative risks from recent meta-analyses to estimate the population attribution fraction (PAF) due to specific modifiable risk factors known to be associated with all-cause mortality within SMI. The potential gain in life expectancy at birth, age 50 and age 65 years were assessed by estimating the combined effect of modifiable risk factors from different contextual levels (behavioural, healthcare, social) and accounting for the effectiveness of existing interventions tackling these factors. Projections for annual gain in life expectancy at birth during a two-decade was estimated using the Annual Percentage Change (APC) formula. The predicted estimates were based on mortality rates for year 2014-2015.
resultsBased on the effectiveness of existing interventions targeting these modifiable risk factors, we estimated potential gain in life expectancy at birth of four (bipolar disorders), six (schizoaffective disorders), or seven years (schizophrenia). The gain in life expectancy at age 50 years was three (bipolar disorders) or five (schizophrenia and schizoaffective disorders) years. The projected gain in life expectancy at age 65 years was three (bipolar disorders) or four (schizophrenia and schizoaffective disorders) years.
conclusionsThe implementation of existing interventions targeting modifiable risk factors could narrow the current mortality gap between the general and the SMI populations by 24% (men) to 28% (women). These projections represent ideal circumstances and without the limitation of overestimation which often comes with PAFs.
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