SynthesisPediatric research2020
Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: a systematic review.
Synthesis in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sonographic Quantification of Venous Circulation in the Preterm Brain
Crossover Study of the Cerebral Blood Flow and Cardiac Output At Different Targeted Tidal Volumes During High Frequency Oscillation with Volume Targeted Ventilation (HFO&VTV)
Comparative Analysis of Cerebral Blood Flow in Term and Preterm Neonates Using Doppler Ultrasonography
Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Microvascular ultrasound imaging of the neonatal brain: a scoping review.European journal of pediatrics · 2026Article
- Tissue Doppler Imaging, Pulmonary Haemodynamics and Conventional Echocardiographic Indices for Early Bronchopulmonary Dysplasia Prediction in Preterm Infants: A Prospective Observational Feasibility Study.Children (Basel, Switzerland) · 2026Article
- Preoperative Hemodynamics and Brain Injury in Transposition of the Great Arteries.JACC. Advances · 2026Article
- Article
- Systemic hypotension and patterns of cerebral blood perfusion in newborns.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Development of a machine learning model to identify intraventricular hemorrhage using time-series analysis in preterm infants.Scientific reports · 2024Article
- Intraoperative transfontanelle ultrasonography for pediatric patients.Anesthesia and pain medicine · 2024Article
- Cranial ultrasound in preterm infants ≤ 32 weeks gestation-novel insights from the use of very high-frequency (18-5 MHz) transducers: a case series.European journal of pediatrics · 2024Article
- Prognostic value of cranial ultrasound findings in infants aged <90 days with bacterial meningitis: a single-centre retrospective cohort study.BMJ paediatrics open · 2024Article
- Neurosonography: Shaping the future of neuroprotection strategies in extremely preterm infants.Heliyon · 2024Review
- Instant Detection of Cerebral Blood Flow Changes in Infants with Congenital Heart Disease during Transcatheter Interventions.Journal of clinical medicine · 2024Article
- [Risk factors for the failure of ibuprofen treatment in preterm infants with hemodynamically significant patent ductus arteriosus].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Correlation of anterior cerebral artery resistive index with early comorbidities in preterm neonates.Frontiers in pediatrics · 2024Article
- Continuous cerebral blood flow monitoring: What should we do with these extra numbers?BJA open · 2023Article
- Neuroimaging of Germinal Matrix and Intraventricular Hemorrhage in Premature Infants.Journal of Korean Neurosurgical Society · 2023Article
- Intraventricular hemorrhage prediction in premature neonates in the era of hemodynamics monitoring: a prospective cohort study.European journal of pediatrics · 2022Observational
- Current understanding and future potential applications of cerebral microvascular imaging in infants.The British journal of radiology · 2022Review
- Low frequency cerebral arterial and venous flow oscillations in healthy neonates measured by NeoDoppler.Frontiers in pediatrics · 2022Article
- Effects of tilt on cerebral hemodynamics measured by NeoDoppler in healthy neonates.Pediatric research · 2021Article
- End-organ saturations correlate with aortic blood flow estimates by echocardiography in the extremely premature newborn - an observational cohort study.BMC pediatrics · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionVery and extremely preterm infants frequently have brain injury-related long-term neurodevelopmental problems. Altered perfusion, for example, seen in the context of a hemodynamically significant patent ductus arteriosus (PDA), has been linked to injury of the immature brain. However, a direct relation with outcome has not been reviewed systematically.
methodsA systematic review was conducted to provide an overview of the value of different cerebral arterial blood flow parameters assessed by Doppler ultrasound, in relation to brain injury, to predict long-term neurodevelopmental outcome in preterm infants.
resultsIn total, 23 studies were included. Because of heterogeneity of studies, a meta-analysis of results was not possible. All included studies on resistance index (RI) showed significantly higher values in subjects with a hemodynamically significant PDA. However, absolute differences in RI values were small. Studies using Doppler parameters to predict brain injury and long-term neurodevelopmental outcome were inconsistent. DISCUSSION: There is no clear evidence to support the routine determination of RI or other Doppler parameters in the cerebral arteries to predict brain injury and long-term neurodevelopmental outcome in the preterm infant. However, there is evidence that elevated RI can point to the presence of a hemodynamically significant PDA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.