Evidence map›Paper›PMID 32218442›Full record

ReviewNature reviews. Disease primers2020

Colonic diverticular disease.

Antonio Tursi, Carmelo Scarpignato, Lisa L Strate, Angel Lanas, Wolfgang Kruis, Adi Lahat, Silvio Danese

Erratum issuedOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 139 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 7 pooled it
25.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 7 syntheses or guidelines pooled it, 227 citations in OpenAlex.

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  10. Natural Language Processing Algorithm Accurately Classifies Diverticulitis-Related Complications and Predicts Long-Term Outcomes.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
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79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 6 countries.

Antonio TursiTerritorial Gastroenterology Service, Azienda Sanitaria Locale Barletta-Andria-Trani, Andria, Italy. antotursi@tiscali.it.
Carmelo ScarpignatoFaculty of Health Sciences, LUdeS Lugano Campus, Lugano, Switzerland.
Lisa L StrateDivision of Gastroenterology, Department of Medicine, Harborview Medical Center, University of Washington Medical School, Seattle, WA, USA.
Angel LanasService of Digestive Diseases, University Clinic Hospital Lozano Blesa, University of Zaragoza, IIS Aragón (CIBERehd), Zaragoza, Spain.
Wolfgang KruisEvangelisches Krankenhaus Kalk, Cologne, Germany.
Adi LahatDepartment of Gastroenterology, Sheba Medical Center, Tel Hashomer, affiliated with Sackler School of Medicine, Tel Aviv University, Ramat Gan, Israel.
Silvio DaneseIBD Center, Department of Gastroenterology, Humanitas Clinical and Research Center - IRCCS -, Rozzano, Italy.
Azienda Sanitaria Locale Alessandria · ITEvangelisches Krankenhaus Kalk · DEHarborview Medical Center · USHospital Clínico Universitario Lozano Blesa · ESHumanitas University · ITLUdeS University · CHTel Aviv University · IL

Funding

Inflammation and Risk of DiverticulitisR01DK101495 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T, STRATE, LISA L · 2014 to 2022
$4.4M
Practice Patterns and Impact of Operative and Non-operative Management of DiverticulitisR01DK103915 · NIDDK · UNIVERSITY OF WASHINGTON · PI FLUM, DAVID R · 2015 to 2019
$2.8M
NIDDK NIH HHS R01 DK101495NIDDK NIH HHS R01 DK103915
6 · The paper itself

Abstract

Diverticula are outpouchings of the intestinal wall and are common anatomical alterations detected in the human colon. Colonic diverticulosis (the presence of diverticula in the colon; referred to as diverticulosis) remains asymptomatic in most individuals but ~25% of individuals will develop symptomatic diverticulosis, termed colonic diverticular disease (also known as diverticular disease). Diverticular disease can range in severity from symptomatic uncomplicated diverticular disease (SUDD) to symptomatic disease with complications such as acute diverticulitis or diverticular haemorrhage. Since the early 2000s, a greater understanding of the pathophysiology of diverticulosis and diverticular disease, which encompasses genetic alterations, chronic low-grade inflammation and gut dysbiosis, has led to improvements in diagnosis and management. Diagnosis of diverticular disease relies on imaging approaches, such as ultrasonography, CT and MRI, as biomarkers alone are insufficient to establish a diagnosis despite their role in determining disease severity and progression as well as in differential diagnosis. Treatments for diverticular disease include dietary fibre, pharmacological treatments such as antibiotics (rifaximin), anti-inflammatory drugs (mesalazine) and probiotics, alone or in combination, and eventually surgery. Despite being effective in treating primary disease, their effectiveness in primary and secondary prevention of complications is still uncertain.

Indexed as

Anti-Bacterial AgentsBiomarkersDiagnostic ImagingDietary FiberDiverticulosis, ColonicGastrointestinal MicrobiomeGastroparesisHumansProbioticsAnti-Bacterial AgentsBiomarkersDietary Fiber

Identifiers

PMID32218442
PMCPMC7486966
OpenAlexW3013092300

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.