Evidence map›Paper›PMID 32218259›Full record

ArticleCancers2020

Biobanking in Molecular Biomarker Research for the Early Detection of Cancer.

Kim Lommen, Selena Odeh, Chiel C de Theije, Kim M Smits

Abstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Circulating Tumor DNA in Pediatric Cancer.Frontiers in molecular biosciences · 2022
    Review
  11. Review
  12. Basic principles of biobanking: from biological samples to precision medicine for patients.Virchows Archiv : an international journal of pathology · 2021
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kim LommenDepartment of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, 6229HX Maastricht, The Netherlands.ORCID 0000-0002-1118-6379
Selena OdehDepartment of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, 6229HX Maastricht, The Netherlands.
Chiel C de TheijeCentral Biobank Maastricht UMC, 6229 ER Maastricht, The Netherlands.
Kim M SmitsDepartment of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, 6229HX Maastricht, The Netherlands.

Funding

Kankeronderzoeksfonds Limburg as part of Health Foundation Limburg 2018-03/KOFLPPP Allowance made available by Health~Holland, Top Sector Life Sciences & Health, to stimulate public-private partnerships LSHM17059 (PRECEDE)
6 · The paper itself

Abstract

Although population-wide screening programs for several cancer types have been implemented in multiple countries, screening procedures are invasive, time-consuming and often perceived as a burden for patients. Molecular biomarkers measurable in non-invasively collected samples (liquid biopsies) could facilitate screening, as they could have incremental value on early diagnosis of cancer, but could also predict prognosis or monitor treatment response. Although the shift towards biomarkers from liquid biopsies for early cancer detection was initiated some time ago, there are many challenges that hamper the development of such biomarkers. One of these challenges is large-scale validation that requires large prospectively collected biobanks with liquid biopsies. Establishing those biobanks involves several considerations, such as standardization of sample collection, processing and storage within and between biobanks. In this perspective, we will elaborate on several issues that need to be contemplated in biobanking, both in general and for certain specimen types specifically, to be able to facilitate biomarker validation for early detection of cancer.

Indexed as

biobankbiomarkerscancerdiagnosisliquid biopsy

Identifiers

PMID32218259
PMCPMC7226426

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.