ArticleBrain sciences2020
Effects of Oral Contraceptive Androgenicity on Visuospatial and Social-Emotional Cognition: A Prospective Observational Trial.
Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- The role of oral contraceptive use in associations of concussion history with kynurenine pathway metabolites, inflammation, and psychological symptoms in female athletes.Brain, behavior, & immunity - health · 2026Article
- Differences in verbal memory, visuospatial ability and cognitive inhibition among young women using drospirenone and ethinyl oestradiol oral contraceptives versus naturally cycling controls.Acta neuropsychiatrica · 2026Article
- Preliminary evidence of increased alcohol use associated with ethinyl estradiol levels in women using oral contraceptives.Drug and alcohol dependence reports · 2023Article
- Morphologic alterations of the fear circuitry: the role of sex hormones and oral contraceptives.Frontiers in endocrinology · 2023Article
- Oral Contraceptives Modulate the Relationship Between Resting Brain Activity, Amygdala Connectivity and Emotion Recognition - A Resting State fMRI Study.Frontiers in behavioral neuroscience · 2022Article
- Intrauterine Device Use: A New Frontier for Behavioral Neuroendocrinology.Frontiers in endocrinology · 2022Article
- Effects of oral contraceptives on spatial cognition depend on pharmacological properties and phase of the contraceptive cycle.Frontiers in endocrinology · 2022Article
- Duration of oral contraceptive use relates to cognitive performance and brain activation in current and past users.Frontiers in endocrinology · 2022Article
- Adherence to Oral Contraception in Young Women: Beliefs, Locus of Control, and Psychological Reactance.International journal of environmental research and public health · 2021Article
- The Specificities of Elite Female Athletes: A Multidisciplinary Approach.Life (Basel, Switzerland) · 2021Review
- Hormones and Cognition.Brain sciences · 2021Article
- Event-Related Potentials in Women on the Pill: Neural Correlates of Positive and Erotic Stimulus Processing in Oral Contraceptive Users.Frontiers in neuroscience · 2021Article
- No Evidence for a Role of Oral Contraceptive-Use in Emotion Recognition But Higher Negativity Bias in Early Follicular Women.Frontiers in behavioral neuroscience · 2021Article
- The Link Between Masculinity and Spatial Skills Is Moderated by the Estrogenic and Progestational Activity of Oral Contraceptives.Frontiers in behavioral neuroscience · 2021Article
- Friend vs. Foe: Cognitive and Affective Empathy in Women With Different Hormonal States.Frontiers in neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral contraceptives (OCs) containing estrogen and progesterone analogues are widely used amongst reproductive-aged women, but their neurocognitive impact is poorly understood. Preliminary studies suggest that OCs improve verbal memory and that OCs with greater androgenic activity may improve visuospatial ability. We sought to explore the cognitive impact of OCs by assessing performance of OC users at different stages of the OC cycle, and comparing this performance between users of different OC formulations according to known androgenic activity. We conducted a prospective, observational trial of OC users, evaluating cognitive performance with CogState software on two occasions: days 7-10 of active hormonal pill phase, and days 3-5 of the inactive pill phase (coinciding with the withdrawal bleed resembling menstruation). Thirty-five OC users (18 taking androgenic formulations, 17 taking anti-androgenic) were assessed. Analysis by androgenic activity showed superior performance by users of androgenic OCs, as compared to anti-androgenic OCs, in visuospatial ability and facial affect discrimination tasks. A growing understanding of cognitive effects of OC progestin androgenicity may have implications in choice of OC formulation for individuals and in future OC development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.