Evidence map›Paper›PMID 32218167›Full record

ArticleCells2020

Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers.

Golam M Uddin, Neil A Youngson, Sabiha S Chowdhury, Christopher Hagan, David A Sinclair, Margaret J Morris

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  3. Trial
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  11. Article
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  13. Article
  14. NADAntioxidants (Basel, Switzerland) · 2023
    Review
  15. NADAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2022
    Review
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Golam M UddinDepartment of Pharmacology, School of Medical Sciences, UNSW Sydney NSW 2052, Australia.
Neil A YoungsonDepartment of Pharmacology, School of Medical Sciences, UNSW Sydney NSW 2052, Australia.
Sabiha S ChowdhuryDepartment of Pharmacology, School of Medical Sciences, UNSW Sydney NSW 2052, Australia.ORCID 0000-0003-0461-4475
Christopher HaganDepartment of Pharmacology, School of Medical Sciences, UNSW Sydney NSW 2052, Australia.
David A SinclairDepartment of Pharmacology, School of Medical Sciences, UNSW Sydney NSW 2052, Australia.
Margaret J MorrisDepartment of Pharmacology, School of Medical Sciences, UNSW Sydney NSW 2052, Australia.ORCID 0000-0003-2285-5117
UNSW Sydney · AUHarvard University · US

Funding

SIRT1 as a regulator of health and lifespan of mammalsR37AG028730 · NIA · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2012 to 2021
$4.1M
Elucidating mechanisms of SIRT1 activationR01DK100263 · NIDDK · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2016 to 2020
$2.5M
NIA NIH HHS R37 AG028730NIDDK NIH HHS R01 DK100263
6 · The paper itself

Abstract

Maternal obesity impacts offspring metabolism. We sought to boost mitochondrial energy metabolism using the nicotinamide adenine dinucleotide (NAD

Indexed as

AnimalsBody WeightDietDiet, High-FatFemaleGene Expression RegulationGlucose Tolerance TestInsulinLiverMaleMice, Inbred C57BLMice, ObeseNicotinamide MononucleotideObesityOrganelle BiogenesisPhenotypeInsulinNicotinamide MononucleotideTriglyceridesmale offspringmaternal obesitymitochondrianicotinamide mononucleotide (NMN)

Identifiers

PMID32218167
PMCPMC7226525
OpenAlexW3013472836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.