Evidence map›Paper›PMID 32217562›Full record

ArticleBMJ open2020

Trends in disease incidence and survival and their effect on mortality in Scotland: nationwide cohort study of linked hospital admission and death records 2001-2016.

Paul R H J Timmers, Joannes J Kerssens, Jon Minton, Ian Grant, James F Wilson, Harry Campbell, Colin M Fischbacher, Peter K Joshi

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Paul R H J TimmersCentre for Global Health Research, The University of Edinburgh Usher Institute, Edinburgh, UK paul.timmers@ed.ac.uk.ORCID 0000-0002-5197-1267
Joannes J KerssensInformation Services Division, NHS National Services Scotland, Edinburgh, UK.
Jon MintonPublic Health Observatory, NHS Health Scotland, Glasgow, UK.
Ian GrantInformation Services Division, NHS National Services Scotland, Edinburgh, UK.
James F WilsonCentre for Global Health Research, The University of Edinburgh Usher Institute, Edinburgh, UK.
Harry CampbellCentre for Global Health Research, The University of Edinburgh Usher Institute, Edinburgh, UK.
Colin M FischbacherInformation Services Division, NHS National Services Scotland, Edinburgh, UK.
Peter K JoshiCentre for Global Health Research, The University of Edinburgh Usher Institute, Edinburgh, UK.ORCID 0000-0002-6361-5059
National Health Service Scotland · GBUniversity of Edinburgh · GBInstitute of Genetics and Cancer · GBPublic Health Scotland · GB

Funding

Medical Research Council MC_UU_00007/10Medical Research Council MR/N013166/1
6 · The paper itself

Abstract

objectivesIdentify causes and future trends underpinning Scottish mortality improvements and quantify the relative contributions of disease incidence and survival.

designPopulation-based study.

settingLinked secondary care and mortality records across Scotland.

participants1 967 130 individuals born between 1905 and 1965 and resident in Scotland from 2001 to 2016.

main outcome measuresHospital admission rates and survival within 5 years postadmission for 28 diseases, stratified by sex and socioeconomic status.

results'Influenza and pneumonia', 'Symptoms and signs involving circulatory and respiratory systems' and 'Malignant neoplasm of respiratory and intrathoracic organs' were the hospital diagnosis groupings associated with most excess deaths, being both common and linked to high postadmission mortality. Using disease trends, we modelled a mean mortality HR of 0.737 (95% CI 0.730 to 0.745) from one decade of birth to the next, equivalent to a life extension of ~3 years per decade. This improvement was 61% (30%-93%) accounted for by improved disease survival after hospitalisation (principally cancer) with the remainder accounted for by lowered hospitalisation incidence (principally heart disease and cancer). In contrast, deteriorations in infectious disease incidence and survival increased mortality by 9% (~3.3 months per decade). Disease-driven mortality improvements were slightly greater for men than women (due to greater falls in disease incidence), and generally similar across socioeconomic deciles. We project mortality improvements will continue over the next decade but slow by 21% because much progress in disease survival has already been achieved.

conclusionMorbidity improvements broadly explain observed mortality improvements, with progress on prevention and treatment of heart disease and cancer contributing the most. The male-female health gaps are closing, but those between socioeconomic groups are not. Slowing improvements in morbidity may explain recent stalling in improvements of UK period life expectancies. However, these could be offset if we accelerate improvements in the diseases accounting for most deaths and counteract recent deteriorations in infectious disease.

Indexed as

AdultAgedAged, 80 and overCause of DeathDeath CertificatesFemaleHealth SurveysHospitalizationHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedMorbidityMortalityScotlandepidemiologypublic health

Identifiers

PMID32217562
PMCPMC7170664
OpenAlexW3013465859

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.