ArticleAJNR. American journal of neuroradiology2020
Hippocampal Sclerosis Detection with NeuroQuant Compared with Neuroradiologists.
Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Technical and clinical validation of commercial automated volumetric MRI tools for dementia diagnosis-a systematic review.Neuroradiology · 2021Pooled it
- Predictors of Drug-Resistant Epilepsy After Perinatal Stroke.Pediatric neurology · 2026Observational
- Article
- Variation in Neurodegeneration-Linked Brain Regions in Young Adult APOE E4 Carriers With Spina Bifida.Annals of the Child Neurology Society · 2025Article
- Towards precision MRI biomarkers in epilepsy with normative modelling.Brain : a journal of neurology · 2025Review
- Voxel-based and surface-based cortical morphometric MRI applications for identifying the epileptogenic zone: A narrative review.Epilepsia open · 2025Review
- Radiologic Classification of Hippocampal Sclerosis in Epilepsy.AJNR. American journal of neuroradiology · 2024Review
- Effects of sleep deprivation on brain atrophy in individuals with mild cognitive impairment and Alzheimer's disease.Ageing research reviews · 2024Article
- Discriminant analysis using MRI asymmetry indices and cognitive scores of women with temporal lobe epilepsy or schizophrenia.Neuroradiology · 2024Article
- Artificial intelligence in epilepsy - applications and pathways to the clinic.Nature reviews. Neurology · 2024Review
- The new era of artificial intelligence in neuroradiology: current research and promising tools.Arquivos de neuro-psiquiatria · 2024Article
- Adding the third dimension: 3D convolutional neural network diagnosis of temporal lobe epilepsy.Brain communications · 2024Article
- Clinical Evaluation of a Quantitative Imaging Biomarker Supporting Radiological Assessment of Hippocampal Sclerosis.Clinical neuroradiology · 2023Article
- Applicability of Automated Brain Volumetry in South Korean Population: Need for Population-Based Database.Journal of the Korean Society of Radiology · 2023Article
- Convolutional Neural Network Algorithm to Determine Lateralization of Seizure Onset in Patients With Epilepsy: A Proof-of-Principle Study.Neurology · 2023Article
- Interpretable deep learning-based hippocampal sclerosis classification.Epilepsia open · 2022Article
- Single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment.Neuroradiology · 2022Article
- Epilepsy in Pediatric Patients-Evaluation of Brain Structures' Volume Using VolBrain Software.Journal of clinical medicine · 2022Article
- Quantification of amyloid PET for future clinical use: a state-of-the-art review.European journal of nuclear medicine and molecular imaging · 2022Review
- Updated Review of the Evidence Supporting the Medical and Legal Use of NeuroQuantFrontiers in human neuroscience · 2022Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
Abstract
background and purposeNeuroQuant is an FDA-approved software that performs automated MR imaging quantitative volumetric analysis. This study aimed to compare the accuracy of NeuroQuant analysis with visual MR imaging analysis by neuroradiologists with expertise in epilepsy in identifying hippocampal sclerosis. MATERIALS AND
methodsWe reviewed 144 adult patients who underwent presurgical evaluation for temporal lobe epilepsy. The reference standard for hippocampal sclerosis was defined by having hippocampal sclerosis on pathology (
resultsNeuroQuant analysis had a similar specificity to neuroradiologist visual MR imaging analysis (90.4% versus 91.6%;
conclusionsVisual MR imaging analysis by a neuroradiologist with expertise in epilepsy had a higher sensitivity than did NeuroQuant analysis, likely due to the inability of NeuroQuant to evaluate changes in hippocampal T2 signal or architecture. Given that there was no significant difference in specificity between NeuroQuant analysis and visual MR imaging analysis, NeuroQuant can be a valuable tool when the results are positive, particularly in centers that lack neuroradiologists with expertise in epilepsy, to help identify and refer candidates for temporal lobe epilepsy resection. In contrast, a negative test could justify a case referral for further evaluation to ensure that false-negatives are detected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.