Evidence map›Paper›PMID 32217415›Full record

ArticleBiomaterials2020

The effect of a nanofiber-hydrogel composite on neural tissue repair and regeneration in the contused spinal cord.

Xiaowei Li, Chi Zhang, Agnes E Haggerty, Jerry Yan, Michael Lan, Michelle Seu, Mingyu Yang, Megan M Marlow, Inés Maldonado-Lasunción, Brian Cho and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  19. Recent Development of Fibrous Hydrogels: Properties, Applications and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Xiaowei LiTranslational Tissue Engineering Center, Baltimore, MD 21205, USA; Department of Materials Science & Engineering, Baltimore, MD 21205, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21205, USA.
Chi ZhangTranslational Tissue Engineering Center, Baltimore, MD 21205, USA; Department of Materials Science & Engineering, Baltimore, MD 21205, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21205, USA; School of Chemistry, Sun Yat-Sen University, Guangzhou, Guangdong 510275, PR China.
Agnes E HaggertyThe Miami Project to Cure Paralysis, University of Miami, Miami, FL 33136, USA.
Jerry YanTranslational Tissue Engineering Center, Baltimore, MD 21205, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
Michael LanTranslational Tissue Engineering Center, Baltimore, MD 21205, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
Michelle SeuTranslational Tissue Engineering Center, Baltimore, MD 21205, USA; Department of Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Mingyu YangTranslational Tissue Engineering Center, Baltimore, MD 21205, USA; Department of Materials Science & Engineering, Baltimore, MD 21205, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21205, USA.
Megan M MarlowThe Miami Project to Cure Paralysis, University of Miami, Miami, FL 33136, USA.
Inés Maldonado-LasunciónThe Miami Project to Cure Paralysis, University of Miami, Miami, FL 33136, USA; Department of Regeneration of Sensorimotor Systems, Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands; Shirley Ryan AbilityLab, Chicago, IL 60611, USA; Department of Physical Therapy and Human Movements Sciences, Chicago, IL 60611, USA; Department of Physiology Northwestern University, Chicago, IL 60611, USA.
Brian ChoTranslational Tissue Engineering Center, Baltimore, MD 21205, USA; Department of Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Zhengbing ZhouTranslational Tissue Engineering Center, Baltimore, MD 21205, USA; Department of Materials Science & Engineering, Baltimore, MD 21205, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21205, USA.
Long ChenTranslational Tissue Engineering Center, Baltimore, MD 21205, USA; Department of Materials Science & Engineering, Baltimore, MD 21205, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21205, USA.
Russell MartinTranslational Tissue Engineering Center, Baltimore, MD 21205, USA; Department of Materials Science & Engineering, Baltimore, MD 21205, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21205, USA.
Yohshiro NitobeThe Miami Project to Cure Paralysis, University of Miami, Miami, FL 33136, USA; Department of Orthopedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, 036-8562, Japan.
Kentaro YamaneThe Miami Project to Cure Paralysis, University of Miami, Miami, FL 33136, USA; Department of Orthopedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science, Kitaku, Okayama, 700-8558, Japan.
Hua YouAffiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510095, PR China.
Sashank ReddyDepartment of Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Da-Ping QuanSchool of Chemistry, Sun Yat-Sen University, Guangzhou, Guangdong 510275, PR China. Electronic address: cesqdp@mail.sysu.ed.cn.
Martin OudegaShirley Ryan AbilityLab, Chicago, IL 60611, USA; Department of Physical Therapy and Human Movements Sciences, Chicago, IL 60611, USA; Department of Physiology Northwestern University, Chicago, IL 60611, USA; Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510095, PR China; Edward Hines Jr. VA Hospital, Hines IL, 60141, USA. Electronic address: moudega@sralab.org.
Hai-Quan MaoTranslational Tissue Engineering Center, Baltimore, MD 21205, USA; Department of Materials Science & Engineering, Baltimore, MD 21205, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: hmao@jhu.edu.

Funding

Promote Organization and Integration of Regenerated Neurons from Transplanted Human Neural Stem CellsR21NS096668 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MAO, HAI-QUAN · 2017 to 2018
$450k
Directed In Vivo Differentiation of Neural Stem Cells for Repair of Brain LesionR21NS085714 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MAO, HAI-QUAN · 2014 to 2015
$446k
Mechanisms of 6-AN facilitated Schwann cell-astrocyte interminglingR21NS101298 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI OUDEGA, MARTIN · 2018 to 2019
$422k
NINDS NIH HHS R21 NS085714NINDS NIH HHS R21 NS096668NINDS NIH HHS R21 NS101298RRD VA I01 RX001807
6 · The paper itself

Abstract

An injury to the spinal cord causes long-lasting loss of nervous tissue because endogenous nervous tissue repair and regeneration at the site of injury is limited. We engineered an injectable nanofiber-hydrogel composite (NHC) with interfacial bonding to provide mechanical strength and porosity and examined its effect on repair and neural tissue regeneration in an adult rat model of spinal cord contusion. At 28 days after treatment with NHC, the width of the contused spinal cord segment was 2-fold larger than in controls. With NHC treatment, tissue in the injury had a 2-fold higher M2/M1 macrophage ratio, 5-fold higher blood vessel density, 2.6-fold higher immature neuron presence, 2.4-fold higher axon density, and a similar glial scar presence compared with controls. Spared nervous tissue volume in the contused segment and hind limb function was similar between groups. Our findings indicated that NHC provided mechanical support to the contused spinal cord and supported pro-regenerative macrophage polarization, angiogenesis, axon growth, and neurogenesis in the injured tissue without any exogenous factors or cells. These results motivate further optimization of the NHC and delivery protocol to fully translate the potential of the unique properties of the NHC for treating spinal cord injury.

Indexed as

NanofibersSpinal Cord InjuriesAnimalsAxonsHydrogelsNerve RegenerationRatsRecovery of FunctionSpinal CordHydrogelsAngiogenesisAxonal growthCompositeHydrogelMacrophage polarizationNanofiberNeurogenesisSpinal cord injury

Identifiers

PMID32217415
PMCPMC8787820

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.