Evidence map›Paper›PMID 32217288›Full record

ArticleRespiratory medicine2020

Cardiopulmonary exercise test indices of respiratory buffering before and after aerobic exercise training in women with pulmonary hypertension: Differentiation by magnitudes of change in six-minute walk test performance.

Z V Morris, L M K Chin, L Chan, A A Guccione, A Ahmad, R E Keyser

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02019641 (The NIH Exercise Therapy for Advanced Lung Disease Trials), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02019641 nacompletednot on this map

The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients With Interstitial Lung Disease

TypeinterventionalSponsorNational Institutes of Health Clinical Center (CC)Ran2015 to 2023Enrolled46ConditionsInterstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Interstitial Pneumonitis, Desquamative Interstitial PneumoniaArmsAerobic Exercise Training (AET), Education
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Exercise-based rehabilitation programmes for pulmonary hypertension.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Z V MorrisDepartment of Rehabilitation Science, George Mason University, Fairfax, VA, USA; Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.
L M K ChinRehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.
L ChanRehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.
A A GuccioneDepartment of Rehabilitation Science, George Mason University, Fairfax, VA, USA.
A AhmadRehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.
R E KeyserDepartment of Rehabilitation Science, George Mason University, Fairfax, VA, USA; Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA. Electronic address: rkeyser@gmu.edu.
George Mason University · USNational Institutes of Health Clinical Center · US

Funding

Effect Of Task On Oral Pressure Dynamics During SwallowiZ01CL060056 · CLC · CLINICAL CENTER · PI CHI-FISHMAN, GLORIA · 2001 to 2006
–
Intramural NIH HHS Z01 CL060056Intramural NIH HHS Z99 CL999999
6 · The paper itself

Abstract

While aerobic exercise training (AET) has generally been shown to improve 6-min walk test (6MWT) distance (6MWD) in patients with pulmonary hypertension (PH), a substantial number of patients appear to adapt differently, with minimal or even negative changes in 6MWT distance being reported. PURPOSE: To compare post-aerobic exercise training adaptations in cardiorespiratory functional capacity across three groups of patients with PH: those with high (HI), low (LI) and negative (NEG) post-training increases in 6MWD.

methodsParticipants were 25 females (age 54 ± 11 years; BMI 31 ± 7 kg/m

resultsPeak CPET duration, WR and time to anaerobic threshold (AT) were significantly higher (p < 0.05) after training in both the LI and HI groups but not in the NEG group. There was a significant improvement in VE/VCO

conclusionThese findings suggest that sustained ventilatory inefficiency and restricted respiratory buffering may mediate exercise intolerance and impede the ability to adapt to exercise training in some patients with PH.

Indexed as

Exercise ToleranceWalk TestAdultAgedExerciseExercise TestExercise TherapyFemaleHumansHypertension, PulmonaryMiddle AgedTreatment OutcomeAerobic exercise trainingPulmonary hypertensionSix-minute walk test

Identifiers

PMID32217288
PMCPMC10367185
OpenAlexW3006411955

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.