Evidence map›Paper›PMID 32217232›Full record

ArticleJournal of affective disorders2020

Female infants are more susceptible to the effects of maternal antenatal depression; findings from the Pelotas (Brazil) Birth Cohort Study.

Elena Netsi, Carolina V N Coll, Alan Stein, Mariangela Freitas Silveira, Andréa Dâmaso Bertoldi, Diego G Bassani, Fernando C Wehrmeister, Marlos Rodrigues Domingues

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In one paragraph

Article in Journal of affective disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elena NetsiDepartment of Psychiatry, Oxford University, Oxford, UK. Electronic address: elena.netsi@psych.ox.ac.uk.
Carolina V N CollPostgraduate Program in Epidemiology, Federal University of Pelotas, Brazil.
Alan SteinDepartment of Psychiatry, Oxford University, Oxford, UK; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Mariangela Freitas SilveiraPostgraduate Program in Epidemiology, Federal University of Pelotas, Brazil.
Andréa Dâmaso BertoldiPostgraduate Program in Epidemiology, Federal University of Pelotas, Brazil.
Diego G BassaniCentre for Global Child Health, The Hospital for Sick Children, Toronto, Canada; Department of Paediatrics, University of Toronto, Canada.
Fernando C WehrmeisterPostgraduate Program in Epidemiology, Federal University of Pelotas, Brazil.
Marlos Rodrigues DominguesPostgraduate Program in Epidemiology, Federal University of Pelotas, Brazil.

Funding

Wellcome TrustWellcome Trust 095582
6 · The paper itself

Abstract

backgroundWe utilised data from the 2015 Pelotas Birth Cohort, a large prospective cohort in southern Brazil, to examine the association of moderate and severe antenatal depression with child birth outcomes and explore interactions with sociodemographic characteristics.

methodsData was available for n = 3046 participants and their infants. We measured antenatal depression using the Edinburgh Postnatal Depression Scale (EPDS, ≥13 for moderate and ≥17 for severe depression). Outcome measures included gestational age, birth weight, length and head circumference, using the Intergrowth-21st standards. We controlled for known confounders including obstetric risk.

resultsWe did not find differences in childbirth outcomes by maternal depression status for participants with at least moderate depression, although there was an increased risk for female offspring to be small for gestational age (SGA, OR 2.33[1.37,3.97]). For severe depression (EPDS≥17) we found an increased risk for lower APGAR scores (OR 1.63[1.02,2.60]) and being SGA (OR 1.77[1.06,2.97], with an increased risk for female offspring in particular to be in lower weight centiles (-10.71 [-16.83,-4.60]), to be SGA (OR 3.74[1.89, 7.44]) and in the lower 10th centile for length (OR 2.19[1.25,3.84]). LIMITATIONS: include the use of a maternal report questionnaire to ascertain depressive symptoms.

conclusionsIn this recent large longitudinal cohort in Brazil we did not find independent effects of depression on adverse birth outcomes or interactions with sociodemographic characteristics. We found an increased risk of being SGA for female offspring of women with moderate and severe depression, in line with other research suggesting females may be more susceptible to antenatal disturbances.

fundingThis work was supported by the Wellcome Trust, United Kingdom (095582), the Brazilian National Research Council (CNPq) and the Coordination for the Improvement of Higher Education Personnel (CAPES). EN was supported by the UK Economic and Social Research Council GCRF Postdoctoral Fellowship (ES/P009794/1).

Indexed as

DepressionBrazilChildCohort StudiesFemaleHumansInfantInfant, NewbornPregnancyProspective StudiesUnited KingdomAntenatal depressionBirth lengthBirth weightSevere depressionSex differencesSmall for gestational age

Identifiers

PMID32217232
PMCPMC7103758

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.