ArticleAmerican journal of obstetrics and gynecology2020
New persistent opioid use after acute opioid prescribing in pregnancy: a nationwide analysis.
Article in American journal of obstetrics and gynecology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07534709 (Suzetrigine Versus Placebo for Opioid-Free Recovery After Cesarean Delivery), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Suzetrigine Versus Placebo for Opioid-Free Recovery After Cesarean Delivery: A Randomized Controlled Trial
Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Evaluation of a mobile application to decrease opioid misuse in patients undergoing cesarean section: a randomized controlled trial.BMC pregnancy and childbirth · 2024Trial
- Opioid Analgesic Use After an Acute Pain Visit: Evidence from a Urolithiasis Patient Cohort.The western journal of emergency medicine · 2022Trial
- Opioid consumption after lower limb amputation in Medicare beneficiaries.PM & R : the journal of injury, function, and rehabilitation · 2025Article
- Postpartum Opioid Use in the United States and the Implications to Maternal and Public Health: A Scoping Review.Maternal and child health journal · 2025Article
- The association between prenatal depression and persistent postpartum pharmaceutical opioid use in six US states.Pregnancy (Hoboken, N.J.) · 2025Article
- Development of an implementation intervention to promote adoption of the COMFORT clinical practice guideline for peripartum pain management: a qualitative study.Implementation science communications · 2025Article
- Can theory-driven implementation interventions help clinician champions promote opioid stewardship after childbirth? Protocol for a pragmatic implementation study.Frontiers in global women's health · 2025Article
- Considering pregnancies as repeated vs independent events: an empirical comparison of common approaches across selected perinatal outcomes.American journal of obstetrics & gynecology MFM · 2024Article
- Risk of Death at 1 Year Following Postpartum Opioid Exposure.American journal of perinatology · 2024Article
- Reducing inpatient opioid consumption after caesarean delivery: effects of an opioid stewardship programme and racial impact in a community hospital.BMJ open quality · 2024Article
- Prescription of oxycodone versus codeine after childbirth and risk of persistent opioid use: a population-based cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Article
- Surgeon Postoperative Opioid Prescribing Intensity and Risk of Persistent Opioid Use Among Opioid-naive Adult Patients: A Population-based Cohort Study.Annals of surgery · 2023Article
- Women's beliefs of pain after childbirth: Critical insight for promoting behavioral strategies to regulate pain and reduce risks for maternal mortality.Patient education and counseling · 2023Article
- The risk of serious opioid-related events associated with common opioid prescribing regimens in the postpartum period after cesarean delivery.American journal of obstetrics & gynecology MFM · 2021Article
- A national evaluation of opioid prescribing and persistent use after ambulatory anorectal surgery.Surgery · 2021Article
- Optimizing opioid prescribing practices after minimally invasive lung resection through a quality-improvement intervention.Canadian journal of surgery. Journal canadien de chirurgieArticle
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the association between opioid prescribing during pregnancy and new persistent opioid use in the year following delivery. MATERIALS AND
methodsThis nationwide retrospective cohort study included patients aged 12-55 years in Optum's deidentified Clinformatics Data Mart Database who were undergoing vaginal delivery or cesarean delivery from 2008 to 2016, with continuous enrollment from 2 years before birth to 1 year postdischarge. Women were included if they were opioid naive in pregnancy (ie, did not fill an opioid prescription 2 years to 9 months before delivery) and did not undergo a procedure within the year after discharge. The exposure was filling an opioid prescription in pregnancy. The primary outcome was new persistent opioid use, defined as a pharmacy claim for ≥1 opioid prescription between 4 and 90 days postdischarge and ≥1 prescription between 91 and 365 days postdischarge. Clinical and demographic covariates were included. Analyses included descriptive statistics and multivariable logistic regression, adjusting for clinical and demographic covariates.
resultsOf 158,425 childbirths identified, 101,013 (63.8%) were by vaginal delivery and 57,412 (36.2%) cesarean delivery. Among all patients, 6.0% (9429) filled an opioid prescription during pregnancy. The factors associated with filling an opioid in pregnancy were having a nondelivery procedure in pregnancy (adjusted odds ratio, 9.60; 95% confidence interval, 8.81-10.47) and having an emergency room visit during pregnancy (adjusted odds ratio, 2.48; 95% confidence interval, 2.37-2.59). Of women who received an opioid in pregnancy, 4% (379) developed new persistent opioid use. The factors most associated with new persistent opioid use were receiving an opioid prescription during pregnancy (adjusted odds ratio, 3.45; 95% confidence interval, 3.04-3.92) and filling a peripartum opioid prescription (1 week prior to 3 days postdischarge) adjusted odds ratio, 2.28, 95% confidence interval (2.02-2.57). Though having a procedure during pregnancy was associated with increased receipt of an opioid prescription, it was also associated with reduced new persistent opioid use (adjusted odds ratio, 0.72; 95% confidence interval, 0.52-0.99).
conclusionWomen who receive an opioid prescription during pregnancy are more likely to experience new persistent opioid use. Maternity care providers must balance pain management in pregnancy with potential risks of opioids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.