Evidence map›Paper›PMID 32217002›Full record

ArticleGynecologic oncology2020

Guideline-concordant treatment is associated with improved survival among women with non-endometrioid endometrial cancer.

Jhalak Dholakia, Elyse Llamocca, Allison Quick, Ritu Salani, Ashley S Felix

Open access · greenAbstract read
In one paragraph

Article in Gynecologic oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Measurement of Treatment Adequacy Influences Racial Disparities Estimates in Endometrial Cancer Care.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  3. Observational
  4. Article
  5. Research with cancer registry data in radiation oncology-current possibilities and perspectives : A narrative review.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Review
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  14. Cancer treatment and survivorship statistics, 2025.CA: a cancer journal for clinicians
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jhalak DholakiaDepartment of Obstetrics and Gynecology, The Ohio State University, Columbus, OH, United States of America.
Elyse LlamoccaDivision of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH, United States of America.
Allison QuickDepartment of Radiation Oncology, The Ohio State University, Columbus, OH, United States of America.
Ritu SalaniDivision of Gynecologic Oncology, College of Medicine, The Ohio State University, Columbus, OH, United States of America.
Ashley S FelixDivision of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH, United States of America. Electronic address: Felix.20@osu.edu.
The Ohio State University · US

Funding

Effect of adiposity changes on endometrial tissue and blood biomarkers in women at increased risk for endometrial cancerK01CA218457 · NCI · OHIO STATE UNIVERSITY · PI FELIX, ASHLEY S. · 2018 to 2022
$703k
NCI NIH HHS K01 CA218457
6 · The paper itself

Abstract

backgroundAmong women diagnosed with non-endometrioid endometrial carcinoma (EC), we investigated associations between race/ethnicity and receipt of guideline-concordant treatment (GCT), as well as relationships between GCT and survival.

methodsWe used the National Cancer Database and identified 21,177 non-Hispanic White (NHW), 6657 non-Hispanic Black (NHB), 1689 Hispanic, and 903 Asian/Pacific Islander (AS/PI) women diagnosed with non-endometrioid EC between 2004 and 2014. Year-specific National Comprehensive Cancer Network (NCCN) guidelines were used to classify GCT. We used multivariable logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between race/ethnicity and GCT receipt. Multivariable-adjusted Cox proportional hazards models were used to estimate hazards ratios (HRs) and 95% CIs for relationships between GCT and overall survival in the total study population and stratified by race/ethnicity.

resultsOverall, 43.8% of women with non-endometrioid EC received GCT. Compared to NHW women, NHB (OR = 1.01, 95% CI = 0.95-1.07), Hispanic (OR = 1.01, 95% CI = 0.91-1.12) and AS/PI women (OR = 1.10, 95% CI = 0.96-1.26) did not have significantly different odds of receiving GCT. GCT was significantly associated with improved survival among NHW (HR = 0.84, 95% CI = 0.80-0.87), NHB (HR = 0.85, 95% CI = 0.80-0.91), and Hispanic women (HR = 0.84, 95% CI = 0.72-0.98) but not among AS/PI women (HR = 0.97, 95% CI = 0.78-1.19).

conclusionsWhile more than half of women with non-endometrioid EC did not receive GCT, no difference in GCT receipt by race/ethnicity was observed. When received, GCT was associated with improved survival in almost all racial groups. Interventions to improve GCT adherence may improve survival for most women with non-endometrioid EC.

Indexed as

AdolescentAdultAgedEndometrial NeoplasmsFemaleHumansMiddle AgedSurvival AnalysisYoung AdultChemotherapyDisparitiesHospital-based cancer registryRaceRadiation treatmentUterus neoplasm

Identifiers

PMID32217002
PMCPMC7293554
OpenAlexW3013587755

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.