ArticleeLife2020
Optimization of energy state transition trajectory supports the development of executive function during youth.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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Who cites it
51 citing papers in PubMed, 91 citations in OpenAlex.
- On the Same Wavelength: The Relationship between Neural Synchrony and Cognitive Ability during Movie Watching in Late Childhood and Early Adolescence.Developmental neuroscience · 2026Article
- Neurochemically informed network control theory reveals energetic dysregulation of altered brain state dynamics in obsessive-compulsive disorder.Psychiatry and clinical neurosciences · 2026Article
- Brain energetic landscapes shape state dysregulation in major depressive disorder: a morphological network controllability perspective.Translational psychiatry · 2026Article
- Brain controllability mediates the effects of early life adversity on adolescent behavior and cognition moderated by genetic risks.Research square · 2026Article
- Inferring intrinsic neural timescales using optimal control theory.Nature communications · 2025Article
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- The Neural Association Between Symptom and Cognition in Major Depressive Disorder: A Network Control Theory Study.Human brain mapping · 2025Article
- Common and unique network basis for externally and internally driven flexibility in cognition: From a developmental perspective.Developmental cognitive neuroscience · 2025Article
- Topographic Axes of Wiring Space Converge to Genetic Topography in Shaping the Human Cortical Layout.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The control costs of human brain dynamics.Network neuroscience (Cambridge, Mass.) · 2025Article
- A network control theory pipeline for studying the dynamics of the structural connectome.Nature protocols · 2024Article
- Hierarchical individual variation and socioeconomic impact on personalized functional network topography in children.BMC medicine · 2024Article
- Altered Structural Connectivity and Functional Brain Dynamics in Individuals With Heavy Alcohol Use Elucidated via Network Control Theory.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Dynamic transient brain states in preschoolers mirror parental report of behavior and emotion regulation.Human brain mapping · 2024Article
- Microstate D as a Biomarker in Schizophrenia: Insights from Brain State Transitions.Brain sciences · 2024Article
- Functional network modules overlap and are linked to interindividual connectome differences during human brain development.PLoS biology · 2024Article
- Body mass index-dependent shifts along large-scale gradients in human cortical organization explain dietary regulatory success.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity.Research square · 2024Article
- The impact of input node placement in the controllability of structural brain networks.Scientific reports · 2024Article
- A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 2 countries.
Funding
Abstract
Executive function develops during adolescence, yet it remains unknown how structural brain networks mature to facilitate activation of the fronto-parietal system, which is critical for executive function. In a sample of 946 human youths (ages 8-23y) who completed diffusion imaging, we capitalized upon recent advances in linear dynamical network control theory to calculate the energetic cost necessary to activate the fronto-parietal system through the control of multiple brain regions given existing structural network topology. We found that the energy required to activate the fronto-parietal system declined with development, and the pattern of regional energetic cost predicts unseen individuals' brain maturity. Finally, energetic requirements of the cingulate cortex were negatively correlated with executive performance, and partially mediated the development of executive performance with age. Our results reveal a mechanism by which structural networks develop during adolescence to reduce the theoretical energetic costs of transitions to activation states necessary for executive function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.