Evidence map›Paper›PMID 32216650›Full record

ArticleJCO global oncology2020

Guidance Statement for the Management of Febrile Neutropenia in Pediatric Patients Receiving Cancer-Directed Therapy in Central America and the Caribbean.

Mario Melgar, Tea Reljic, Guillermo Barahona, Kattia Camacho, Alicia Chang, Johanny Contreras, Darrell Espinoza, Dora Estripeaut, Mario Gamero, Marco Luque and 6 more

Open access · goldAbstract read
In one paragraph

Article in JCO global oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Observational
  2. Implementation of an electronic registry to monitor quality of care for febrile episodes in pediatric patients with cancer in Central America and the Caribbean.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Survey of practices for the clinical management of febrile neutropenia in children in hematology-oncology units in Latin America.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 7 countries.

Mario MelgarUnidad Nacional de Oncología Pediátrica, Guatemala City, Guatemala.
Tea ReljicDepartment of Internal Medicine, University of South Florida, Tampa, FL.
Guillermo BarahonaHospital Nacional de Niños Benjamín Bloom, San Salvador, El Salvador.
Kattia CamachoHospital Nacional de Niños Dr. Carlos Sáenz Herrera, San José, Costa Rica.
Alicia ChangUnidad Nacional de Oncología Pediátrica, Guatemala City, Guatemala.
Johanny ContrerasHospital Infantil Dr Robert Reid Cabral, Santo Domingo, Dominican Republic.
Darrell EspinozaHospital Infantil Manuel de Jesus Rivera "La Mascota," Managua, Nicaragua.
Dora EstripeautHospital del Niño Dr José Renán Esquivel, Panama, Panama.
Mario GameroHospital Nacional de Niños Benjamín Bloom, San Salvador, El Salvador.
Marco LuqueHospital Escuela Universitario, Tegucigalpa, Honduras.
Girlande MentorHôpital Saint Damien, Tabarre, Haiti.
Pamela ZacasaHospital Escuela Universitario, Tegucigalpa, Honduras.
Maysam HomsiDepartment of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN.
Miguela A CanizaDepartment of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN.
Ambuj KumarDepartment of Internal Medicine, University of South Florida, Tampa, FL.
Sheena MukkadaDepartment of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN.
St. Jude Children's Research Hospital · USHospital Nacional de Niños Bloom · SVUniversidad Metropolitana de Honduras · HNUniversity of South Florida · USHospital del Niño · PAHospital Infantil Dr. Robert Reid Cabral · DOHospital Infantil Manuel de Jesús Rivera · NIHospital Nacional de Niños · CR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOur objective was to provide regionally appropriate, resource-conscious recommendations for the diagnosis and treatment of pediatric patients with febrile neutropenia.

methodsA multinational panel of Central American and Caribbean clinicians who deliver pediatric oncology care prioritized clinically important questions and then used the Grading of Recommendations Assessment, Development and Evaluation methodology to provide recommendations on the selected topics.

resultsTwenty-two questions and 2 definitions were included in the guideline, which was intended to establish minimum care standards for pediatric patients treated in regional centers. Of all the included studies, 6.9% were conducted in low- and middle-income countries, and no studies were performed in countries represented on the panel.

conclusionThe panel made recommendations on the basis of existing evidence but identified important gaps in knowledge from the region and from resource-limited settings that may affect the clinical applicability of these recommendations. These deficiencies suggest a research agenda that will enable future guidelines to be more responsive to the local context.

Indexed as

Febrile NeutropeniaNeoplasmsCaribbean RegionCentral AmericaChildHumansMedical Oncology

Identifiers

PMID32216650
PMCPMC7124939
OpenAlexW3013228683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.